C2497
Anti-CPSF1 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-CPSF160, Anti-Cleavage and polyadenylation specific factor 1, 160kDa, Anti-HSU37012, Anti-P/cl.18
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~160 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): 5-10 μg using lysate of HEK-293T cells over expressing human CPSF1
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... CPSF1(29894)
mouse ... Cpsf1(94230)
rat ... Cpsf1(366952)
应用
Anti-CPSF1 (C-terminal) antibody produced in rabbit is suitable for immunoprecipitation at a working amount of 5-10μg using lysate of HEK-293T cells over expressing human CPSF1.
生化/生理作用
Cleavage and polyadenylation specificity factor subunit 1 is a protein encoded by the CPSF1 gene in humans. CPSF1 is the largest subunit of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1 and is located in the nucleus. CPSF is a multi-subunit protein that plays a central role in 3′ processing of mammalian pre-mRNAs. CPF interacts directly with the AAUAAA recognition signal in the RNA and is required for the cleavage as well as for the subsequent polyadenylation reaction during 3′ processing of messenger RNA precursors.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Qin Yang et al.
Wiley interdisciplinary reviews. RNA, 2(5), 732-747 (2011-08-09)
3' processing is an essential step in the maturation of all messenger RNAs (mRNAs) and is a tightly coupled two-step reaction: endonucleolytic cleavage at the poly(A) site is followed by the addition of a poly(A) tail, except for metazoan histone
W Keller et al.
The EMBO journal, 10(13), 4241-4249 (1991-12-01)
Cleavage and polyadenylation factor (CPF) is required for the cleavage as well as for the subsequent polyadenylation reaction during 3' processing of messenger RNA precursors. Here, we have investigated the interaction of CPF and poly(A) polymerase with short RNA substrates.
K G Murthy et al.
Genes & development, 9(21), 2672-2683 (1995-11-01)
Cleavage-polyadenylation specificity factor (CPSF) is a multisubunit protein that plays a central role in 3' processing of mammalian pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis.
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