C2505
肾上腺酮
≥92% (HPLC), powder, corticosteroid hormone
别名:
11β,21-二羟丙酮-4-孕烯-3,20-二酮, 11β,21-二羟基黄体酮, 4-孕烯-11β,21-二醇-3,20-二酮, Kendall化合物B, Reichstein物质H
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关于此项目
经验公式（希尔记法）:
C21H30O4
化学文摘社编号:
分子量:
346.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
200-019-6
MDL number:
Beilstein/REAXYS Number:
2339601
产品名称
肾上腺酮, ≥92%
InChI
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
SMILES string
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
biological source
synthetic (organic)
assay
≥92%
form
powder
mp
179-183 °C (lit.)
solubility
chloroform: 50 mg/mL, clear, colorless to faintly yellow
shipped in
ambient
storage temp.
room temp
Quality Level
Gene Information
human ... EBP(10682), SERPINA6(866)
rat ... Ar(24208), Nr3c1(24413)
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相关类别
Biochem/physiol Actions
皮质酮是肾上腺皮质分泌的一种糖皮质激素，可同时激活盐皮质激素和糖皮质激素受体。
皮质酮通过11β-羟化酶（主要存在于肾上腺中）反应合成,但也可在非肾上腺组织中合成，包括睾丸间质细胞和小鼠胸腺。皮质酮在下丘脑-垂体-肾上腺(HPA)轴激活后释放。它对调节新陈代谢、免疫功能和应激反应很关键。皮质酮由髓系细胞应激时的HPA激活产生。在亨廷顿病中可观察到皮质酮水平升高。
Application
皮质酮已用于：
- 慢性治疗，研究对小鼠生长激素抑制素(SST)神经元的影响
- 作为孕鼠应激诱导激素
- 测试对小鼠抑郁相关行为的影响
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
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