C2898
Choline Acetyltransferase from human placenta
suitable for assay of choline, ammonium sulfate suspension, ≥20 units/mg protein (biuret)
别名:
AChT, Acetyl-CoA: choline O-acetyltransferase, CAT
form
ammonium sulfate suspension
specific activity
≥20 units/mg protein (biuret)
suitability
suitable for assay of choline
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... CHAT(1103)
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Biochem/physiol Actions
Choline acetyltransferase (AChT) is a major enzyme in the synthesis of acetylcholine (ACh) in cholinergic neurons.
Physical form
Suspension in 2.8 M (NH4)2SO4 containing 5 mM potassium phosphate, pH 7.4, 0.5 mM EDTA and 0.5 mM dithiothreitol
Analysis Note
Actual protein content given on label.
Other Notes
One unit will catalyze the transfer of 1.0 nanomole of acetate from 14C-acetyl CoA to choline per min at pH 7.5 at 37°C.
法规信息
新产品
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Yoshihiko Kakinuma et al.
PloS one, 7(11), e50761-e50761 (2012-12-05)
In our previous study, we established the novel concept of a non-neuronal cardiac cholinergic system--cardiomyocytes produce ACh in an autocrine and/or paracrine manner. Subsequently, we determined the biological significance of this system--it played a critical role in modulating mitochondrial oxygen
Jun Liang et al.
Neuroscience letters, 532, 59-63 (2012-11-28)
In Alzheimer's disease patients, dysfunction of the cholinergic neurons is one of the causes of cognitive disorders. Although there is still no effective cure for theses diseases and conditions, some promising strategies are currently available to replace these damaged cells.
Dale F Sharrad et al.
Neuroscience letters, 534, 171-176 (2012-11-06)
The discrete functional classes of enteric neurons in the mammalian gastrointestinal tract have been successfully distinguished on the basis of the unique combination of molecules and enzymes in their cell bodies ("chemical coding"). Whether the same chemical coding exists in
M Zalecki et al.
Autonomic neuroscience : basic & clinical, 171(1-2), 21-27 (2012-10-30)
The goal of the present study was to examine the precise localization of the brainstem motor and primary sensory (nodose ganglion) vagal perikarya supplying the pylorus in the domestic pig. Using the Fast Blue retrograde tracing technique it has been
N Kayadjanian et al.
The European journal of neuroscience, 11(10), 3659-3668 (1999-11-17)
The regulation of the striatal m1 and m4 muscarinic receptor mRNA as well as the choline acetyltransferase (ChAT) mRNA expression by nigral dopaminergic and cortical glutamatergic afferent fibres was investigated using quantitative in situ hybridization histochemistry. The effects induced by
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