生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen (caspase 8a) 55 kDa
antigen (caspase 8b) 54 kDa
种属反应性
human
技术
microarray: suitable
western blot: 1:1,000 using human Burkitt lymphoma Raji cell extract
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... CASP8(841)
免疫原
synthetic peptide of the human caspase 8a/MACHα1 precursor (amino acids 362-374 with N-terminal added lysine), conjugated to KLH.
应用
Anti-Caspase 8 (GD-13) is suitable for microarray. It is also suitable for western blot at a concentration of 1:1,000 using human Burkitt lymphoma Raji cell extract.
生化/生理作用
Caspase 8 cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. It also cleaves ADPRT. Caspase 8 hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. It is also a target for cowpox virus CRMA death inhibitory protein. Anti-Caspase 8 (GD-13) recognizes human caspase 8a (55 kDa) and caspase 8b (54kDa) by immunoblotting. Staining of caspase 8 in immunoblotting is specifically inhibited with caspase 8 immunizing peptide (human, amino acids 362-374). Caspases play a crucial role in apoptosis in almost every cell type.
The sequence used as the immunogen corresponds to the C-terminal region of the enzyme p18 subunit and is identical in other human caspase 8 isoforms (MACHα2, MACHα3, MACHβ) and has limited homology (approx. 50%) to mouse caspase 8. By immunoblotting, the antibody reacts with caspase 8a and caspase 8b.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
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