C2992
CFTR Inhibitor-172
≥98% (HPLC), powder, CFTR inhibitor
别名:
5-[（4-羧基苯基）亚甲基]-2-硫氧-3- [（3-三氟甲基）苯基-4-噻唑烷酮
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关于此项目
经验公式（希尔记法）:
C18H10F3NO3S2
化学文摘社编号:
分子量:
409.40
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
CFTR（inh）-172, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
yellow
溶解性
DMSO: ≥10 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
OC(=O)c1ccc(cc1)\C=C2\SC(=S)N(C2=O)c3cccc(c3)C(F)(F)F
InChI
1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8+
InChI key
JIMHYXZZCWVCMI-RIYZIHGNSA-N
应用
CFTR（inh）-172用于特异性抑制囊性纤维化跨膜电导调节因子（CFTR）的活性。也可用作 CFTR抑制剂 Inh-172处理福司柯林（毛喉素）和IBMX。
生化/生理作用
CFTR (inh)-172 是囊性纤维化跨膜传导调节因子 (CFTR) 的抑制剂。
CFTR (inh)-172 是囊性纤维化跨膜传导调节因子 (CFTR) 的抑制剂。K i = 300 nM。CFTR (inh)-172 导致快速、可逆和非电压依赖性抑制；为动物止泻药。CTFR (inh)-172 可能是研究霍乱和其他分泌性腹泻囊性纤维化和肠液丢失动物模型的有用工具。CTFR (inh)-172 在结构上与已知的非特异性 CFTR 抑制剂 DPC，NPPB（货号N4779）和格列本脲。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Tonghui Ma et al.
The Journal of clinical investigation, 110(11), 1651-1658 (2002-12-05)
Secretory diarrhea is the leading cause of infant death in developing countries and a major cause of morbidity in adults. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is required for fluid secretion in the intestine and airways and, when
Electrophysiological evaluation of cystic fibrosis conductance transmembrane regulator (CFTR) expression in human monocytes
Ettorre M, et al.
Biochimica et biophysica acta. General subjects, 1840(10), 3088-3095 (2014)
N D Sonawane et al.
Journal of pharmaceutical sciences, 94(1), 134-143 (2005-03-12)
A small-molecule inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR), 3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone (CFTR(inh)-172), reduces enterotoxin-induced intestinal fluid secretion in rodents. Here, we study CFTR(inh)-172 pharmacology and antidiarrheal efficacy in rodents using (14)C-labeled CFTR(inh)-172, liquid chromatography/mass spectrometry, and a closed intestinal
Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis
Sorio C, et al.
Testing, 6(7), e22212-e22212 (2011)
An unexpected effect of TNF-alpha on F508del-CFTR maturation and function
Bitam S, et al.
F1000Research, 4 (2015)
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