biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
contains
15 mM sodium azide
technique(s)
Ouchterlony double diffusion: 1:16, dot blot: 1:20,000, indirect ELISA: 1:8,000
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
抗血清可与霍乱毒素反应，但与葡萄球菌肠毒素A和葡萄球菌肠毒素B和假单胞菌外毒素A（蛋白浓度：50-500 ng / dot）无反应。尚未检测本品对活性霍乱毒素的中和效力。
霍乱毒素是霍乱的病原体，由按照AB5的化学计量组装的两个亚基A（27 kDa）和B（12 kDa）组成。 B亚基可与位于肠上皮细胞膜中的特定受体单唾液酸神经节苷脂 GM1结合。A亚基的A1片段可改变位置穿过宿主细胞膜，并催化腺苷酸环化酶复合物的Gsa调节成分的ADP核糖基化。由此导致的循环AMP水平的增加促进了多种作用，包括肠上皮细胞氯离子的分泌。
Immunogen
霍乱弧菌毒素
Application
兔抗霍乱毒素抗体可用于：
- 蛋白质印迹
- 神经节苷脂依赖性定量酶联免疫检测（ELISA）
- 双向免疫扩散
Biochem/physiol Actions
霍乱毒素（CT）是一种多功能蛋白，在免疫系统中起一定作用。它具有免疫调节、佐剂特性，还可以用作消炎药。其免疫调节特性可用于治疗多种自身免疫性疾病。CT是多功能蛋白的最佳模型之一。
Preparation Note
脱脂
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Clémence Merlen et al.
The FEBS journal, 272(17), 4385-4397 (2005-09-01)
We have defined the in vivo and in vitro metabolic fate of internalized cholera toxin (CT) in the endosomal apparatus of rat liver. In vivo, CT was internalized and accumulated in endosomes where it underwent degradation in a pH-dependent manner.
A A S Baptista et al.
Poultry science, 93(1), 39-45 (2014-02-27)
This study investigated the immune response of broiler chickens with oral treatment of a Lactobacillus spp. pool (PL) associated with microencapsulated recombinant proteins flagellin (FliC) and the subunit B of cholera toxin (CTB). Immune responses were evaluated by measuring IgA
Christine A Pellino et al.
Journal of bacteriology, 198(11), 1621-1630 (2016-03-24)
Shiga toxin (Stx)-producing Escherichia coli (STEC) is a major cause of foodborne illness, including the life-threatening complication hemolytic-uremic syndrome. The German outbreak in 2011 resulted in nearly 4,000 cases of infection, with 54 deaths. Two forms of Stx, Stx1 and
Purified cholera toxin B subunit from transgenic tobacco plants possesses authentic antigenicity
Wang XG, et al.
Biotechnology and Bioengineering, 72(4), 490-494 (2001)
Qiyao Wang et al.
Infection and immunity, 83(9), 3381-3395 (2015-06-10)
Diverse environmental stimuli and a complex network of regulatory factors are known to modulate expression of Vibrio cholerae's principal virulence factors. However, there is relatively little known about how metabolic factors impinge upon the pathogen's well-characterized cascade of transcription factors
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C3062-1ML | 04061837860522 |
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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