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C3093

Chloroethylclonidine 二盐酸盐

Name: Chloroethylclonidine 二盐酸盐
Brand: SIGMA

别名:

2-[2,6-Dichloro(N-β-chloroethyl-N-methyl)-4-aminomethyl]phenylimino-2-imidazolidine dihydrochloride, CEC dihydrochloride

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₇Cl₃N₄ · 2HCl

化学文摘社编号:

70107-07-2

分子量:

408.58

UNSPSC Code:

12352200

MDL number:

MFCD00055181

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属性

SMILES string

Cl.Cl.CN(CCCl)Cc1cc(Cl)c(\N=C2/NCCN2)c(Cl)c1

InChI

1S/C13H17Cl3N4.2ClH/c1-20(5-2-14)8-9-6-10(15)12(11(16)7-9)19-13-17-3-4-18-13;;/h6-7H,2-5,8H2,1H3,(H2,17,18,19);2*1H

InChI key

CZSAXNDACBPMAB-UHFFFAOYSA-N

说明

Application

Irreversible α_1b adrenergic alkylating agent

Biochem/physiol Actions

Irreversible α_1B-adrenoceptor alkylating agent.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Potent inhibitory action of chlorethylclonidine on the positive inotropic effect and phosphoinositide hydrolysis mediated via myocardial alpha 1-adrenoceptors in the rabbit ventricular myocardium.

M Takanashi et al.

Naunyn-Schmiedeberg's archives of pharmacology, 343(6), 669-673 (1991-06-01)

The influence of the alpha 1b-adrenoceptor-selective antagonist chlorethylclonidine on the alpha 1-adrenergic positive inotropic effect and the phosphoinositide hydrolysis induced by phenylephrine was investigated in the rabbit ventricular myocardium. Pretreatment of membrane fractions derived from the rabbit ventricular muscle with

Estradiol regulates responsiveness of the dorsal premammillary nucleus of the hypothalamus and affects fear- and anxiety-like behaviors in female rats.

Yoav Litvin et al.

The European journal of neuroscience, 40(2), 2344-2351 (2014-05-28)

Research suggests a causal link between estrogens and mood. Here, we began by examining the effects of estradiol (E2 ) on rat innate and conditioned defensive behaviors in response to cat odor. Second, we utilized whole-cell patch clamp electrophysiological techniques