C3490
Cyclofenil
≥98% (HPLC), white, solid
别名:
4,4′-Cyclohexylidenemethylenediphenol, 4-(Cyclohexylidenemethylene)-bis-phenol
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关于此项目
经验公式（希尔记法）:
C23H24O4
化学文摘社编号:
分子量:
364.43
UNSPSC Code:
51111800
PubChem Substance ID:
EC Number:
220-089-1
MDL number:
InChI key
GVOUFPWUYJWQSK-UHFFFAOYSA-N
InChI
1S/C23H24O4/c1-16(24)26-21-12-8-19(9-13-21)23(18-6-4-3-5-7-18)20-10-14-22(15-11-20)27-17(2)25/h8-15H,3-7H2,1-2H3
SMILES string
CC(=O)Oc1ccc(cc1)\C(=C2\CCCCC2)c3ccc(OC(C)=O)cc3
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
Gene Information
human ... ESR1(2099), ESR2(2100)
Biochem/physiol Actions
Cyclofenil is a selective estrogen receptor β antagonist.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
D Drecktrah et al.
Journal of cell science, 111 ( Pt 7), 951-965 (1998-05-20)
Previous studies have shown that the Golgi stack and the trans-Golgi network (TGN) may play a role in capturing escaped resident endoplasmic reticulum (ER) proteins, and directing their retrograde transport back to that organelle. Whether this retrograde movement represents a
Hua Zhu et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 15(4), 591-599 (2010-03-03)
To develop technetium- and rhenium-labeled nonsteroidal estrogen imaging agents for estrogen receptor (ER) positive breast tumors, two groups of rhenium and technetium cyclofenil derivatives were synthesized and characterized. The binding affinities of the rhenium complexes for ERs were determined. The
Infertility and subfertility.
Kirsten Duckitt
Clinical evidence, (11)(11), 2427-2458 (2005-01-18)
Karen J Kieser et al.
Journal of medicinal chemistry, 53(8), 3320-3329 (2010-03-26)
Selective estrogen receptor (ER) down-regulators (SERDs) reduce ERalpha protein levels as well as block ER activity and therefore are promising therapeutic agents for the treatment of hormone refractory breast cancer. Starting with the triarylethylene acrylic acid SERD 4, we have
Peter Gärtner et al.
Journal of mass spectrometry : JMS, 43(7), 958-964 (2008-06-26)
The detection of metabolites of the anti-estrogenic substance cyclofenil, listed on the World Anti-Doping Agency (WADA) Prohibited List since 2004 is described. Target substances are hydroxylated metabolites, bearing an aliphatic hydroxyl group either in the 2-, 3- or 4-position of
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