C3490
Cyclofenil
≥98% (HPLC), white, solid
别名:
4,4′-Cyclohexylidenemethylenediphenol, 4-(Cyclohexylidenemethylene)-bis-phenol
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: ≥10 mg/mL
储存温度
2-8°C
SMILES字符串
CC(=O)Oc1ccc(cc1)\C(=C2\CCCCC2)c3ccc(OC(C)=O)cc3
InChI
1S/C23H24O4/c1-16(24)26-21-12-8-19(9-13-21)23(18-6-4-3-5-7-18)20-10-14-22(15-11-20)27-17(2)25/h8-15H,3-7H2,1-2H3
InChI key
GVOUFPWUYJWQSK-UHFFFAOYSA-N
基因信息
human ... ESR1(2099), ESR2(2100)
生化/生理作用
Cyclofenil is a selective estrogen receptor β antagonist.
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Peter Gärtner et al.
Journal of mass spectrometry : JMS, 43(7), 958-964 (2008-06-26)
The detection of metabolites of the anti-estrogenic substance cyclofenil, listed on the World Anti-Doping Agency (WADA) Prohibited List since 2004 is described. Target substances are hydroxylated metabolites, bearing an aliphatic hydroxyl group either in the 2-, 3- or 4-position of
Karen J Kieser et al.
Journal of medicinal chemistry, 53(8), 3320-3329 (2010-03-26)
Selective estrogen receptor (ER) down-regulators (SERDs) reduce ERalpha protein levels as well as block ER activity and therefore are promising therapeutic agents for the treatment of hormone refractory breast cancer. Starting with the triarylethylene acrylic acid SERD 4, we have
G Rossi et al.
The Italian journal of gastroenterology, 24(2), 77-78 (1992-02-01)
The case of a 47-year old woman suffering from acute hepatitis caused by cyclofenil, a drug proposed for the treatment of anovulation and scleroderma, is presented. Hepatitis developed seven weeks after the beginning of administration of the drug and its
Hua Zhu et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 15(4), 591-599 (2010-03-03)
To develop technetium- and rhenium-labeled nonsteroidal estrogen imaging agents for estrogen receptor (ER) positive breast tumors, two groups of rhenium and technetium cyclofenil derivatives were synthesized and characterized. The binding affinities of the rhenium complexes for ERs were determined. The
Infertility and subfertility.
Kirsten Duckitt
Clinical evidence, (11)(11), 2427-2458 (2005-01-18)
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