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C4127

Z-D-Phe-OH

Name: Z-<SC>D</SC>-Phe-OH
Brand: SIGMA

别名:

N-Cbz-D-phenylalanine, Z-D-phenylalanine

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₇NO₄

化学文摘社编号:

2448-45-5

分子量:

299.32

UNSPSC Code:

12352202

NACRES:

NA.26

PubChem Substance ID:

24892665

MDL number:

MFCD00063151

Beilstein/REAXYS Number:

4355833

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属性

form

solid

application(s)

peptide synthesis

storage temp.

−20°C

SMILES string

OC(=O)[C@@H](Cc1ccccc1)NC(=O)OCc2ccccc2

InChI

1S/C17H17NO4/c19-16(20)15(11-13-7-3-1-4-8-13)18-17(21)22-12-14-9-5-2-6-10-14/h1-10,15H,11-12H2,(H,18,21)(H,19,20)/t15-/m1/s1

InChI key

RRONHWAVOYADJL-OAHLLOKOSA-N

说明

Application

N-Cbz-D-phenylalanine is used for affinity chromatography of proteinases such as the extracellular fibrinogenolytic enzyme of Aspergillus fumigatus.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Extracellular fibrinogenolytic enzyme of Aspergillus fumigatus: substrate-dependent variations in the proteinase synthesis and characterization of the enzyme.

J P Bouchara et al.

FEMS immunology and medical microbiology, 7(1), 81-91 (1993-06-01)

To get a better understanding of the role of the previously reported fibrinogenolytic enzyme of Aspergillus fumigatus, we investigated the in vitro conditions of enzyme synthesis and attempted to characterize it. Modification of the nitrogen source did not influence the

Solution conformation of the thermolysin inhibitors carbobenzoxy-L-phenylalanine and beta-phenylpropionyl-L-phenylalanine and comparison of the solution conformation to the enzyme-bound conformation.

T L Shieh et al.

Journal of medicinal chemistry, 25(4), 403-408 (1982-04-01)

The conformations of enzyme inhibitors in solution and bound to the enzyme thermolysin are investigated as a convenient model for understanding the relationship between the conformation of drugs in solution and at the receptor. The solution conformations of carbobenzoxy-L-phenylalanine (I)

Selective suppression of cathepsin L results from elevations in lysosomal pH and is followed by proteolysis of tau protein.

E Bednarski et al.

Neuroreport, 9(9), 2089-2094 (1998-07-23)

Incubation of cultured hippocampal slices with chloroquine, a compound that increases the pH of acidic subcellular organelles, for 10 h reduced the activity of cathepsin L by 83 +/- 0.87% (mean +/- s.e.m.) while only marginally suppressing cathepsin B. This

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全球贸易项目编号

货号	GTIN
C4127-25G	04061832415949