C4520
头孢菌素 钠盐
别名:
7-(2-Thienylacetamido)cephalosporanic acid sodium salt, Cephalotin sodium salt
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关于此项目
经验公式（希尔记法）:
C16H15N2NaO6S2
化学文摘社编号:
分子量:
418.42
UNSPSC Code:
51282506
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-394-6
Beilstein/REAXYS Number:
4120706
MDL number:
InChI key
VUFGUVLLDPOSBC-XRZFDKQNSA-M
InChI
1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10;/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23);/q;+1/p-1/t12-,15-;/m1./s1
SMILES string
[Na+].CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C([O-])=O
form
crystalline powder
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
Quality Level
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General description
Chemical structure: β-lactam
Application
Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics, and for immunology studies in relation to antibiotics. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Mode of Action: Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.
Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.
Mode of Resistance: Production of cephalosporinase will inactivate the product.
Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.
Mode of Resistance: Production of cephalosporinase will inactivate the product.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
J V Desiderio et al.
The Journal of infectious diseases, 148(3), 563-570 (1983-09-01)
Multilamellar liposomes (lipid bilayer vesicles) composed of phosphatidylcholine, cholesterol, and phosphatidylserine (molar ratio, 6:3:1) were produced and then made to entrap an aqueous solution of cephalothin. Resident murine peritoneal macrophages were shown to be capable of interiorizing the liposome-antibiotic complex;
S Mobashery et al.
The Journal of biological chemistry, 261(17), 7879-7887 (1986-06-15)
Two novel C10-(dipeptidyl)cephalosporin esters (3-(beta-chloro-L-alanyl-beta-chloro-L-alanyloxymethyl)-7 beta-(2-thienylacetamido)-3-cephem-4-carboxylic acid (7) and sodium 3-(L-alanyl-L-alanyloxymethyl)-7 beta-(2-thienylacetamido)-3-cephem-4-carboxylate, toluene-sulfonic acid salt (18] were synthesized, and their reactions with Escherichia coli TEM beta-lactamase were examined. Kinetic parameters determined for the enzymatic reactions of 7 (Km = 0.32
Studies on the immune response to penicillin and cephalothin in humans. I. Optimal conditions for titration of hemagglutinating penicillin and cephalothin antibodies.
P Spath et al.
Journal of immunology (Baltimore, Md. : 1950), 107(3), 854-859 (1971-09-01)
Esteban C Nannini et al.
Antimicrobial agents and chemotherapy, 54(5), 2206-2208 (2010-03-10)
Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no
Chun-Hsien Lin et al.
Peptides, 36(1), 114-120 (2012-05-09)
The in vitro activity of mastoparan-AF, an amphipathic antimicrobial peptide isolated from the hornet venom of Vespa affinis, alone and in combination with various clinically used antibiotics, was investigated against 21 Escherichia coli isolates/strains. Most E. coli isolates tested were
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