C4714
Calreticulin from bovine liver
≥90% (SDS-PAGE), lyophilized powder
方案
≥90% (SDS-PAGE)
表单
lyophilized powder
分子量
~60 kDa
杂质
salt, essentially free
UniProt登记号
储存温度
−20°C
基因信息
cow ... CALR(281036)
生化/生理作用
A high-affinity calcium binding protein which plays a dynamic role in calcium homeostasis. In addition, calreticulin binds directly to the DNA domain of hormone receptors as well as to the regulatory cytoplasmic domain of proteins of the integrin family. Calreticulin has also been shown to possess a chaperone function.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
I Wada et al.
The Journal of biological chemistry, 270(35), 20298-20304 (1995-09-01)
A unique type of chaperone that requires glucose trimming of the target proteins has been shown to be important for their maturation in the endoplasmic reticulum (ER). Calnexin, an ER membrane chaperone, is the first example of such a class.
Novel functions for calreticulin: interaction with integrins and modulation of gene expression?
S Dedhar
Trends in biochemical sciences, 19(7), 269-271 (1994-07-01)
L Mery et al.
The Journal of biological chemistry, 271(16), 9332-9339 (1996-04-19)
The widely distributed and highly conserved Ca(2+)-binding protein calreticulin has been suggested to play a role as a Ca2+ storage protein of intracellular Ca+ stores. To test this hypothesis, we have generated a mouse L fibroblast cell line stably transfected
K Burns et al.
Nature, 367(6462), 476-480 (1994-02-03)
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin has been
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