assay
≥90% (SDS-PAGE)
form
lyophilized powder
mol wt
~60 kDa
impurities
salt, essentially free
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... CALR(281036)
Biochem/physiol Actions
A high-affinity calcium binding protein which plays a dynamic role in calcium homeostasis. In addition, calreticulin binds directly to the DNA domain of hormone receptors as well as to the regulatory cytoplasmic domain of proteins of the integrin family. Calreticulin has also been shown to possess a chaperone function.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Novel functions for calreticulin: interaction with integrins and modulation of gene expression?
S Dedhar
Trends in biochemical sciences, 19(7), 269-271 (1994-07-01)
L Mery et al.
The Journal of biological chemistry, 271(16), 9332-9339 (1996-04-19)
The widely distributed and highly conserved Ca(2+)-binding protein calreticulin has been suggested to play a role as a Ca2+ storage protein of intracellular Ca+ stores. To test this hypothesis, we have generated a mouse L fibroblast cell line stably transfected
K Burns et al.
Nature, 367(6462), 476-480 (1994-02-03)
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin has been