C4915
S-(+)-Chlorpheniramine maleate salt
别名:
(S)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate salt
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关于此项目
经验公式（希尔记法）:
C16H19ClN2 · C4H4O4
化学文摘社编号:
分子量:
390.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
219-450-6
MDL number:
Form:
powder
Quality level:
form
powder
Quality Level
originator
Bayer
SMILES string
[H]\C(=C(/[H])C(O)=O)C(O)=O.CN(C)CC[C@@H](c1ccc(Cl)cc1)c2ccccn2
InChI
1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1
InChI key
DBAKFASWICGISY-DASCVMRKSA-N
Gene Information
human ... HRH1(3269)
General description
Chlorpheniramine maleate is a cationic amphiphilic anti-histamine agent, which is composed of a hydrophobic ring structure and a hydrophilic side chain with a charged cationic amino group.
Application
S-(+)-Chlorpheniramine maleate salt has been used to study the anticholinergic effect of Achillea millefolium and Portulaca olerace on muscarinic receptors of guinea pig tracheal smooth muscle.
Biochem/physiol Actions
H1 histamine receptor antagonist; active isomer.
Chlorpheniramine maleate is clinically used as a topical ointment to treat skin disorders such as sunburn, urticaria, angioedema, pruritus and insect bites.
Chlorpheniramine maleate is clinically used as a topical ointment to treat skin disorders such as sunburn, urticaria, angioedema, pruritus and insect bites.
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Rana Keyhanmanesh et al.
Planta medica, 76(3), 218-222 (2009-08-28)
In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic, effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. In the present study, the prophylactic effect of thymoquinone (one of the constituents of Nigella sativa) on tracheal
Y Sugimoto et al.
Immunopharmacology, 48(1), 1-7 (2000-05-24)
An animal model of chronic allergic rhinitis was developed by repeated local booster sensitization into the nasal cavity in sensitized rats. The severity of allergic rhinitis was assessed by determining the extent of two markers of nasal allergic symptoms (sneezing
Y Akaishi et al.
British journal of pharmacology, 130(4), 907-915 (2000-06-24)
We investigated the effect of stimulation of H(1)-receptors with histamine on protein tyrosine phosphorylation levels in guinea-pig left atrium and evaluated the influences of tyrosine kinase inhibitors on the positive inotropic effect mediated by H(1)-receptors in this tissue. Histamine induced
Azadeh Feizpour et al.
Indian journal of pharmacology, 45(1), 13-17 (2013-04-02)
To investigate one possible mechanism for the observed relaxant effect of A. millefolium (Achillea millefolium), in the present study the inhibitory effect of the extract of this plant on muscarinic receptors was examined. The effects of three concentrations of aqueous-ethanolic
Portulaca olerace Affects Muscarinic Receptors of Guinea Pig Tracheal Smooth Muscle.
Indian Journal of Pharmaceutical Sciences, 78, 388-394 (2016)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C4915-1G | 04061833493793 |
| C4915-5G | 04061833493960 |
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