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Merck
CN

C4991

Sigma-Aldrich

头孢甘氨酸

≥97% (HPLC), solid

别名:

NSC 318735

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关于此项目

经验公式(希尔记法):
C45H53NO14
化学文摘社编号:
分子量:
831.90
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平

方案

≥97% (HPLC)

表单

solid

溶解性

DMSO: soluble 14 mg/mL

抗生素抗菌谱

neoplastics

作用机制

DNA synthesis | interferes

储存温度

room temp

SMILES字符串

C\C=C(/C)C(=O)N[C@H]([C@@H](O)C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)C4[C@@](C)([C@@H](O)C[C@H]5OC[C@@]45OC(C)=O)C(=O)[C@H](OC(C)=O)C(=C1C)C2(C)C)c6ccccc6

InChI

1S/C45H53NO14/c1-9-23(2)39(52)46-33(27-16-12-10-13-17-27)34(50)41(54)58-29-21-45(55)38(59-40(53)28-18-14-11-15-19-28)36-43(8,30(49)20-31-44(36,22-56-31)60-26(5)48)37(51)35(57-25(4)47)32(24(29)3)42(45,6)7/h9-19,29-31,33-36,38,49-50,55H,20-22H2,1-8H3,(H,46,52)/b23-9+/t29-,30-,31+,33-,34+,35+,36?,38-,43+,44-,45+/m0/s1

InChI key

DBXFAPJCZABTDR-UJLUYDJNSA-N

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一般描述

化学结构:β-内酰胺

应用

头孢甘氨酸已被用于鉴定液体培养物中的真菌紫杉醇(抗癌药)。

生化/生理作用

三尖杉宁碱是一种具有抗肿瘤、抗增殖特性的紫杉醇衍生物。
头孢甘氨酸是从红豆杉中分离得到的,可用作抗真菌剂。

象形图

CorrosionExclamation mark

警示用语:

Danger

危险声明

危险分类

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Kannan Vivekanandan et al.
Rapid communications in mass spectrometry : RCM, 20(11), 1731-1735 (2006-05-06)
A strategy is developed for the identification of isocephalomannine in the presence of alkali metal ion adducts and other cephalomannine isomers in a paclitaxel active pharmaceutical ingredient. Intact molecular ion analyses and a sub-structural study have been performed for the
Jiang-Wei Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(2), 418-426 (2007-11-28)
To investigate how taxane's substituents at C3' affect its metabolism, we compared the metabolism of cephalomannine and paclitaxel, a pair of analogs that differ slightly at the C3' position. After cephalomannine was incubated with human liver microsomes in an NADPH-generating
K C Chan et al.
Journal of chromatography. B, Biomedical applications, 657(2), 301-306 (1994-07-15)
High-performance liquid chromatography (HPLC) and micellar electrokinetic chromatography (MEKC) were applied for the separation of taxol, cephalomannine, and baccatin III in crude extracts from the needle and bark of Taxus species. The chromatogram of the bark extract was cleaner than
G Moyna et al.
Journal of chemical information and computer sciences, 36(6), 1224-1227 (1996-11-01)
A simple iterative method for superimposing sets of NMR derived structures and calculation of the root mean square deviation (RMSD) of the sets is described. It was compared to the commonly used algorithm involving pairwise best fitting in the conformational
Interactions between co-habitating fungi elicit synthesis of Taxol from an endophytic fungus in host Taxus plants
Soliman Sameh SM and Raizada MN
Frontiers in Microbiology, 4, 3-3 (2013)

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