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C4991

头孢甘氨酸

Name: 头孢甘氨酸
Brand: SIGMA

≥97% (HPLC), solid

别名:

NSC 318735

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关于此项目

经验公式（希尔记法）:

C₄₅H₅₃NO₁₄

化学文摘社编号:

71610-00-9

分子量:

831.90

NACRES:

NA.77

PubChem Substance ID:

24724441

UNSPSC Code:

12352200

MDL number:

MFCD01075131

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥97% (HPLC)

form

solid

solubility

DMSO: soluble 14 mg/mL

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

storage temp.

room temp

SMILES string

C\C=C(/C)C(=O)N[C@H]([C@@H](O)C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)C4[C@@](C)([C@@H](O)C[C@H]5OC[C@@]45OC(C)=O)C(=O)[C@H](OC(C)=O)C(=C1C)C2(C)C)c6ccccc6

InChI

1S/C45H53NO14/c1-9-23(2)39(52)46-33(27-16-12-10-13-17-27)34(50)41(54)58-29-21-45(55)38(59-40(53)28-18-14-11-15-19-28)36-43(8,30(49)20-31-44(36,22-56-31)60-26(5)48)37(51)35(57-25(4)47)32(24(29)3)42(45,6)7/h9-19,29-31,33-36,38,49-50,55H,20-22H2,1-8H3,(H,46,52)/b23-9+/t29-,30-,31+,33-,34+,35+,36?,38-,43+,44-,45+/m0/s1

InChI key

DBXFAPJCZABTDR-UJLUYDJNSA-N

General description

化学结构:β-内酰胺

Application

头孢甘氨酸已被用于鉴定液体培养物中的真菌紫杉醇（抗癌药）。

Biochem/physiol Actions

头孢甘氨酸是从红豆杉中分离得到的，可用作抗真菌剂。

三尖杉宁碱是一种具有抗肿瘤、抗增殖特性的紫杉醇衍生物。

pictograms

GHS05,GHS07

signalword

Danger

hcodes

H315,H318,H335

pcodes

P280 - P302 + P352 - P305 + P351 + P338 + P310

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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历史批次信息供参考:

分析证书(COA)

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Lx2-32c, a novel taxane and its antitumor activities in vitro and in vivo.

Hongbo Wang et al.

Cancer letters, 268(1), 89-97 (2008-05-17)

Lx2-32c, a novel taxane derivative, is a semisynthetic analogue from cephalomannine. Its antitumor activity in vivo and in vitro was investigated in this study. Lx2-32c was cytotoxic (IC50=1.7+/-1.6nM) to various human tumor cell lines after 72h incubation. In vitro it

A simple algorithm for superimposing sets of NMR derived structures: its application to the conformational study of cephalomannine in lipophobic and lipophilic solution.

G Moyna et al.

Journal of chemical information and computer sciences, 36(6), 1224-1227 (1996-11-01)

A simple iterative method for superimposing sets of NMR derived structures and calculation of the root mean square deviation (RMSD) of the sets is described. It was compared to the commonly used algorithm involving pairwise best fitting in the conformational

Taxane's substituents at C3' affect its regioselective metabolism: different in vitro metabolism of cephalomannine and paclitaxel.

Jiang-Wei Zhang et al.

Drug metabolism and disposition: the biological fate of chemicals, 36(2), 418-426 (2007-11-28)

To investigate how taxane's substituents at C3' affect its metabolism, we compared the metabolism of cephalomannine and paclitaxel, a pair of analogs that differ slightly at the C3' position. After cephalomannine was incubated with human liver microsomes in an NADPH-generating

High-performance liquid chromatography and micellar electrokinetic chromatography of taxol and related taxanes from bark and needle extracts of Taxus species.

K C Chan et al.

Journal of chromatography. B, Biomedical applications, 657(2), 301-306 (1994-07-15)

High-performance liquid chromatography (HPLC) and micellar electrokinetic chromatography (MEKC) were applied for the separation of taxol, cephalomannine, and baccatin III in crude extracts from the needle and bark of Taxus species. The chromatogram of the bark extract was cleaner than

Identification of isocephalomannine in the presence of cephalomannine isomers and alkali metal ion adducts in a paclitaxel active pharmaceutical ingredient using electrospray tandem mass spectrometry.

Kannan Vivekanandan et al.

Rapid communications in mass spectrometry : RCM, 20(11), 1731-1735 (2006-05-06)

A strategy is developed for the identification of isocephalomannine in the presence of alkali metal ion adducts and other cephalomannine isomers in a paclitaxel active pharmaceutical ingredient. Intact molecular ion analyses and a sub-structural study have been performed for the

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全球贸易项目编号

货号	GTIN
C4991-5MG	04061833494165
C4991-1MG	04061826744130

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