C5367
Monoclonal Anti-Casein Kinase 2α antibody produced in mouse
~2 mg/mL, clone 1AD9, purified immunoglobulin, buffered aqueous solution
别名:
Anti-CK2α
生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
1AD9, monoclonal
表单
buffered aqueous solution
分子量
antigen ~35 kDa
种属反应性
rat, mouse, human
浓度
~2 mg/mL
技术
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 2-4 μg/mL using total cell extract of MCF7 cells.
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CSNK2A1(1457)
mouse ... Csnk2a1(12995)
rat ... Csnk2a1(116549)
一般描述
CK2 is a ubiquitously expressed serine/threonine kinase that has been implicated in various cellular functions such as cell death, cell cycle regulation, and mRNA synthesis. This protein kinase comprises of two catalytic α subunits and two dimeric β subunits that associate to form a heterotetrameric enzyme complex.CK2 is also involved in regulating viral infections . Monoclonal Anti-Casein Kinase 2α antibody is specific for casein kinase 2 α in humans, rats and mice (approx. 35 kDa). The antibody-binding epitope resides within amino acids 319-324 of human CK2α. This epitope is conserved across several species.
免疫原
human denatured recombinant casein kinase 2α.
应用
Monoclonal Anti-Casein Kinase 2α antibody is suitable for use in immunoprecipitation and western blot assays using human fibroblasts . The product can also be used for indirect ELISA and microarray applications.
外形
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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N A St-Denis et al.
Cellular and molecular life sciences : CMLS, 66(11-12), 1817-1829 (2009-04-24)
Protein kinase CK2 is a serine/threonine kinase with a multitude of protein substrates. The enzyme is ubiquitously expressed in mammalian cells, where it functions in a variety of cellular processes, including cell cycle progression, apoptosis, transcription, and viral infection. While
Yang Gao et al.
Journal of virology, 82(1), 96-104 (2007-10-26)
Human cytomegalovirus (HCMV) UL84 is a phosphoprotein that shuttles from the nucleus to the cytoplasm and is required for oriLyt-dependent DNA replication and viral growth. UL84 was previously shown to interact with IE2 (IE86) in infected cells, and this interaction
Inessa Ermakova et al.
Journal of molecular biology, 330(5), 925-934 (2003-07-16)
Protein kinase CK2 (formerly called: casein kinase 2) is a heterotetrameric enzyme composed of two separate catalytic chains (CK2alpha) and a stable dimer of two non-catalytic subunits (CK2beta). CK2alpha is a highly conserved member of the superfamily of eukaryotic protein
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