C5423
克仑特罗 盐酸盐
≥95% (TLC), powder, β2-adrenoceptor agonist
别名:
4-氨基-& # 945;-（叔丁基氨基甲基）-3,5-二氯苄醇 盐酸盐
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关于此项目
经验公式（希尔记法）:
C12H18Cl2N2O · HCl
化学文摘社编号:
分子量:
313.65
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
克仑特罗 盐酸盐, ≥95%
质量水平
方案
≥95%
表单
powder
drug control
Home Office Schedule 4.2
储存温度
2-8°C
SMILES字符串
Cl.CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1
InChI
1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H
InChI key
OPXKTCUYRHXSBK-UHFFFAOYSA-N
基因信息
human ... ADRB2(154)
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应用
盐酸克伦特罗已被用作：
- 来自鸡骨骼肌的 β-肾上腺素能受体（＆＃946; -AR）的激动剂，以诱导大鼠
- 的咬肌、二腹肌和颞肌中的肥大效应。
- 作为串联质谱（MS-MS）中的参照β-激动剂标准
生化/生理作用
盐酸克伦特罗是一种& # 946；2-肾上腺素受体激动剂和支气管扩张剂。它能有效改善哮喘患者的呼气峰流速（PEFR）。克伦特罗也是一种提高性能的药物，因为它刺激中枢神经系统并改善氧转运。克伦特罗在扩张型心肌病患者中引发心脏保护功能。
警示用语：
Danger
危险声明
危险分类
Carc. 2 - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
兴奋剂蛋白同化制剂
此项目有
beta1-and beta2-adrenergic receptor stimulation differ in their effects on PGC-1alpha and atrogin-1/MAFbx gene expression in chick skeletal muscle
Shimamoto S, et al.
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 211, 1-6 (2017)
H M Zuurmond et al.
Molecular pharmacology, 56(5), 909-916 (1999-10-26)
Previously, we demonstrated the involvement of Asn293 in helix VI of the human beta(2)-adrenergic receptor in stereoselective agonist recognition and activation. In the present study, we have further explored the role of this residue by synthesizing derivatives of isoproterenol and
Effects of clenbuterol, a beta2-adrenergic agonist, on sizes of masseter, temporalis, digastric, and tongue muscles
Ishikawa C, et al.
The Open Dentistry Journal, 3, 191-191 (2009)
beta2-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats
Zhang Q, et al.
British Journal of Pharmacology, 160(6), 1561-1572 (2010)
Clinton E Canal et al.
Learning & memory (Cold Spring Harbor, N.Y.), 15(9), 677-686 (2008-09-06)
Infusions of CREB antisense into the amygdala prior to training impair memory for aversive tasks, suggesting that the antisense may interfere with CRE-mediated gene transcription and protein synthesis important for the formation of new memories within the amygdala. However, the
Chromatograms
application for HPLC
application for HPLC
application for HPLC
application for HPLC
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