C5423
克仑特罗 盐酸盐
≥95% (TLC), powder, β2-adrenoceptor agonist
别名:
4-氨基-& # 945;-（叔丁基氨基甲基）-3,5-二氯苄醇 盐酸盐
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经验公式（希尔记法）:
C12H18Cl2N2O · HCl
化学文摘社编号:
分子量:
313.65
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-643-7
MDL number:
产品名称
克仑特罗 盐酸盐, ≥95%
InChI
1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H
InChI key
OPXKTCUYRHXSBK-UHFFFAOYSA-N
SMILES string
Cl.CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1
assay
≥95%
form
powder
drug control
Home Office Schedule 4.2
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADRB2(154)
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Application
盐酸克伦特罗已被用作：
- 来自鸡骨骼肌的 β-肾上腺素能受体（＆＃946; -AR）的激动剂，以诱导大鼠
- 的咬肌、二腹肌和颞肌中的肥大效应。
- 作为串联质谱（MS-MS）中的参照β-激动剂标准
Biochem/physiol Actions
盐酸克伦特罗是一种& # 946；2-肾上腺素受体激动剂和支气管扩张剂。它能有效改善哮喘患者的呼气峰流速（PEFR）。克伦特罗也是一种提高性能的药物，因为它刺激中枢神经系统并改善氧转运。克伦特罗在扩张型心肌病患者中引发心脏保护功能。
signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
兴奋剂蛋白同化制剂
此项目有
I Semkova et al.
Brain research. Brain research reviews, 30(2), 176-188 (1999-10-19)
Neurotrophins and other neurotrophic factors have been shown to support the survival and differentiation of many neuronal populations of the central and peripheral nervous system. Therefore, administering neurotrophic factors could represent an alternative strategy for the treatment of acute and
Jelka Pleadin et al.
Meat science, 86(3), 733-737 (2010-07-30)
The aim of this study was to determine the level of clenbuterol residues in muscle tissue of pigs after repeat administration in a growth-promoting dose. An anabolic dose of clenbuterol (20 μg/kg body mass per day) was administered orally to
C A Izeboud et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 48(9), 497-502 (1999-10-16)
To investigate the suppressive effects of the beta-agonist clenbuterol on the release of TNF-alpha and IL-6 in a lipopolysaccharide (LPS)-model of inflammation, both in vitro and in vivo. Human U-937 cell line (monocyte-derived macrophages), and male Wistar rats (200-250 g).
A trial of clenbuterol in bronchial asthma.
Anderson G and Wilkins E
Thorax, 32(6), 717-719 (1977)
H M Zuurmond et al.
Molecular pharmacology, 56(5), 909-916 (1999-10-26)
Previously, we demonstrated the involvement of Asn293 in helix VI of the human beta(2)-adrenergic receptor in stereoselective agonist recognition and activation. In the present study, we have further explored the role of this residue by synthesizing derivatives of isoproterenol and
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