C6046
20-羧基-白三烯B4
~1 mg/mL in ethanol, ≥90% (HPLC)
别名:
20-Carboxy-LTB4
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关于此项目
经验公式（希尔记法）:
C20H30O6
化学文摘社编号:
分子量:
366.45
UNSPSC Code:
12352211
PubChem Substance ID:
MDL number:
InChI
1S/C20H30O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-18,21-22H,1,3,9-11,14-16H2,(H,23,24)(H,25,26)/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m1/s1
SMILES string
O[C@@H](CCCC(O)=O)/C=C\C=C\C=C\[C@H](O)C\C=C/CCCCC(O)=O
InChI key
SXWGPVJGNOLNHT-VFLUTPEKSA-N
assay
≥90% (HPLC)
form
liquid
concentration
~1 mg/mL in ethanol
functional group
carboxylic acid
shipped in
dry ice
storage temp.
−20°C
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
57.2 °F
flash_point_c
14 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
M Yamane et al.
Journal of chromatography. B, Biomedical applications, 666(2), 197-202 (1995-04-21)
A method for the analysis of omega-carboxyleukotriene B4 and omega-hydroxyleukotriene B4 in human colonic carcinoma homogenate is described. The hydroxy groups of the leukotriene metabolite were acetylated by acetic anhydride, and the mixture was partially purified on a Sep-Pak C18
H Sumimoto et al.
The Journal of biological chemistry, 265(8), 4348-4353 (1990-03-15)
Leukotriene B4 (LTB4), a potent chemoattractant for leukocytes, is catabolized by human neutrophils via omega-oxidation. Neutrophil microsomes are known to oxidize 20-hydroxy-LTB4 (20-OH-LTB4) to its 20-oxo and 20-carboxy derivatives in the presence of NADPH. This activity has been ascribed to
P Borgeat et al.
Prostaglandins, 35(5), 723-731 (1988-05-01)
The 5S, 12S-dihydroxy-6,8,10,14-(E,Z,E,Z,)-eicosatetraenoic acid, a product of double dioxygenation of arachidonic acid by lipoxygenases, undergoes severe decomposition during gas chromatography-mass spectrometric (GC-MS) analysis of the trimethylsilyl ether methyl ester derivative. The decomposition product was studied by GC-MS and identified as
W Schönfeld et al.
Prostaglandins, leukotrienes, and medicine, 27(2-3), 227-236 (1987-05-01)
The generation and metabolism of leukotrienes (LTs) from polymorphonuclear granulocytes of four polytraumatic patients on stimulation with the Ca-Ionophore A 23187 were studied by high performance liquid chromatography. In contrast to healthy donors the concentration of LTB4 within the supernatant
Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes.
G Hansson et al.
FEBS letters, 130(1), 107-112 (1981-07-20)
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