SMILES string
Clc1cccc(Nc2nnc(-c3ccccc3)c4ccccc24)c1
assay
≥98%
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
I D Duarte et al.
European journal of pharmacology, 217(2-3), 225-227 (1992-07-07)
We tested the hypothesis that activation of the nitric oxide (NO)-cGMP pathway is involved in the mechanism of two directly acting non-opiate peripheral analgesics, myrcene and dipyrone, using our modification of the Randall-Selitto test. The NO inhibitor, NG-monomethyl-L-arginine (50 micrograms/paw)
F Lanza et al.
Thrombosis research, 45(5), 477-484 (1987-03-01)
Cyclic nucleotide phosphodiesterase inhibitors (HL-725, RO 15-2041, cilostamide, quercetin and MY-5445) potently inhibit human platelet aggregation induced by ADP. In parallel, PDE inhibitors inhibit the increase in cytoplasmic free Ca2+ evoked by ADP, as measured with the fluorescent probe quin
The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release.
S H Ferreira et al.
European journal of pharmacology, 201(1), 121-122 (1991-08-16)
I D Duarte et al.
Mediators of inflammation, 9(1), 25-30 (2000-07-06)
NG-nitro-L-arginine methyl ester (L-NAME) has been used extensively as a paradigmatic inhibitor of NO synthase and has been shown to cause antinociception in several experimental models. We describe here how L-NAME produced a dose-dependent antinociceptive effect when injected intraperitoneally in
S H Ferreira et al.
Agents and actions. Supplements, 32, 101-106 (1991-01-01)
We have previously described the peripheral analgesic effect of dibutyryl cyclic GMP, acetylcholine (ACh) and morphine (Mph) injected into the rat paws. Since ACh induces nitric oxide (NO) release from endothelial cells which is though to stimulate guanylate cyclase (GC)
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