产品名称
钙蛋白酶1 人, aqueous glycerol solution
assay
≥95% (SDS-PAGE)
form
aqueous glycerol solution
specific activity
≥1000 U/mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CAPN1(823)
Application
人类钙蛋白酶 1 已用在一项研究中评估人类钙蛋白酶 1 和 9 的晶体结构是如何暗示各种作用和自抑制机制的。人钙蛋白酶 1 也已用于研究 N 杂环二肽醛（作为选择性钙蛋白酶抑制剂）的合成、生物学评估和分子模型研究。
Biochem/physiol Actions
胞质蛋白酶作为上游调节剂参与细胞骨架重塑、自噬和细胞凋亡。
钙蛋白酶 1 是含有 EF 手基序的中性钙依赖性半胱氨酸蛋白酶。蛋白酶由两个亚基组成；较大的亚基具有四个与木瓜蛋白酶和钙调蛋白同源的结构域。较小的亚基具有一个与钙调蛋白具有同源性的结构域。它被微摩尔水平的钙激活，因此也被称为微钙蛋白酶。它的激活导致细胞蛋白降解、神经元细胞变性和自身免疫性脱髓鞘疾病，例如多发性硬化。
General description
钙蛋白酶 1 是异二聚体钙激活的巯基蛋白酶。
Other Notes
在25 °C 下，每分钟一个单位水解1皮摩尔的Suc-LLVY-AMC。
Physical form
在 20 mM 咪唑-HCl，5 mM β-巯基乙醇，1 mM EDTA，1 mM EGTA 和 30％ 甘油中的溶液。
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
高风险级别生物产品--人源产品
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