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Merck
CN

C6235

Sigma-Aldrich

Crosstide

≥97% (HPLC), lyophilized powder

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化学文摘社编号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
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方案

≥97% (HPLC)

表单

lyophilized powder

分子量

calculated mol wt 1164

组成

Peptide content, ≥65%

溶解性

H2O: soluble

储存温度

−20°C

SMILES字符串

C[C@@H](O)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(O)=O

InChI

1S/C48H77N17O17/c1-24(38(74)59-28(14-15-35(70)71)39(75)56-21-36(72)73)57-41(77)30(19-26-9-4-3-5-10-26)61-42(78)31(22-66)62-43(79)32(23-67)63-45(81)37(25(2)68)64-40(76)27(11-6-16-54-47(50)51)60-44(80)33-13-8-18-65(33)46(82)29(58-34(69)20-49)12-7-17-55-48(52)53/h3-5,9-10,24-25,27-33,37,66-68H,6-8,11-23,49H2,1-2H3,(H,56,75)(H,57,77)(H,58,69)(H,59,74)(H,60,80)(H,61,78)(H,62,79)(H,63,81)(H,64,76)(H,70,71)(H,72,73)(H4,50,51,54)(H4,52,53,55)/t24-,25+,27-,28-,29-,30-,31-,32-,33-,37-/m0/s1

InChI key

KJAXEBRGQOHHOY-VXRVIWLSSA-N

基因信息

human ... AKT1(207)
mouse ... AKT1(11651)
rat ... AKT1(24185)

Amino Acid Sequence

Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly

应用

Crosstide has been used as a positive control in serine/threonine-protein kinase (akt) assay to test phosphorylation of serine 404 residue in lamin A It has also been used as a substrate for Akt in in vitro kinase

生化/生理作用

Crosstide is a serine/threonine-protein kinase (Akt) or protein kinase B β (PKBβ) substrate.

其他说明

Sequence from glycogen synthase kinase-3β

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number

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Karen Tan et al.
Diabetes, 56(3), 714-719 (2007-03-01)
We previously reported a family in which a heterozygous missense mutation in Akt2 led to a dominantly inherited syndrome of insulin-resistant diabetes and partial lipodystrophy. To determine whether genetic variation in AKT2 plays a broader role in human metabolic disease
Vittoria Cenni et al.
Journal of proteome research, 7(11), 4727-4735 (2008-09-24)
Akt/PKB is a central activator of multiple signaling pathways coupled with a large number of stimuli. Although both localization and activity of Akt in the nuclear compartment are well-documented, most Akt substrates identified so far are located in the cytoplasm
R Meier et al.
The Journal of biological chemistry, 272(48), 30491-30497 (1997-12-31)
Protein kinase B (PKB) is a member of the second messenger-dependent family of serine/threonine kinases that has been implicated in signaling pathways downstream of growth factor receptor tyrosine kinases and phosphatidylinositol 3-kinase. Here we report the characterization of the human

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