C6455
氯霉素，大包装
Sigma Reference Standard, powder
别名:
D-(−)-苏-2,2-二氯-N-[β-羟基-α-(羟甲基)-β-(4-硝基苯基)乙基]乙酰胺, D-(−)-苏-2-二氯乙酰胺基-1-(4-硝基苯基)-1,3-丙二醇, D-苏-2,2-二氯-N-β[-羟基-α-(羟甲基)-4-硝基苯乙基]乙酰胺, 氯霉素
表单
powder
包装
vial of 200 mg
颜色
white
mp
149-153 °C (lit.)
抗生素抗菌谱
viruses
作用机制
protein synthesis | interferes
储存温度
2-8°C
SMILES字符串
OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
InChI
1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChI key
WIIZWVCIJKGZOK-RKDXNWHRSA-N
基因信息
human ... CYP1A2(1544)
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一般描述
Chemical structure: phenicole
应用
Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.
生化/生理作用
作用机制：氯霉素通过与50S核糖体亚基结合并阻止氨酰基tRNA附着于核糖体来阻断肽基转移酶步骤，从而抑制细菌蛋白质的合成。 它还抑制线粒体和叶绿体蛋白的合成以及（p）ppGpp的核糖体形成，从而抑制rRNA的转录。
耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。
抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。
耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。
抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。
Mode of Action: Inhibits cell wall protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit.
Antimicrobial spectrum: Gram-positive cocci.
Mode of Resistance: Cephalosporinase production.
Antimicrobial spectrum: Gram-positive cocci.
Mode of Resistance: Cephalosporinase production.
包装
Supplied in amber screw-cap vials
警示用语：
Danger
危险声明
危险分类
Carc. 2 - Eye Dam. 1 - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
Uwe Richter et al.
Current biology : CB, 23(6), 535-541 (2013-03-05)
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Anthony J Brzoska et al.
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Members of the genus Acinetobacter have been the focus recent attention due to both their clinical significance and application to molecular biology. The soil commensal bacterium Acinetobacter baylyi ADP1 has been proposed as a model system for molecular and genetic
J N de Almeida Júnior et al.
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Trichosporon spp. have recently emerged as significant human pathogens. Identification of these species is important, both for epidemiological purposes and for therapeutic management, but conventional identification based on biochemical traits is hindered by the lack of updates to the species
David G Kirk et al.
Applied and environmental microbiology, 80(16), 5141-5150 (2014-06-15)
Clostridium botulinum produces heat-resistant endospores that may germinate and outgrow into neurotoxic cultures in foods. Sporulation is regulated by the transcription factor Spo0A and the alternative sigma factors SigF, SigE, SigG, and SigK in most spore formers studied to date.
David H Kwan et al.
Journal of the American Chemical Society, 137(17), 5695-5705 (2015-04-15)
Blood transfusions are critically important in many medical procedures, but the presence of antigens on red blood cells (RBCs, erythrocytes) means that careful blood-typing must be carried out prior to transfusion to avoid adverse and sometimes fatal reactions following transfusion.
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