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C6491

Chrysomycin B

Name: Chrysomycin B
Brand: SIGMA

≥98% (HPLC), solid

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关于此项目

经验公式（希尔记法）:

C₂₇H₂₈O₉

化学文摘社编号:

83852-56-6

分子量:

496.51

NACRES:

NA.77

PubChem Substance ID:

24892870

UNSPSC Code:

12352200

MDL number:

MFCD07370132

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属性

assay

≥98% (HPLC)

form

solid

solubility

DMF: soluble, DMSO: soluble, ethanol: moderately soluble, methanol: moderately soluble

antibiotic activity spectrum

neoplastics

mode of action

enzyme | inhibits

storage temp.

2-8°C

SMILES string

COc1cc(C)cc2C(=O)Oc3c(cc(OC)c4c(O)ccc([C@@H]5O[C@H](C)[C@H](O)[C@@](C)(O)[C@H]5O)c34)-c12

InChI

1S/C27H28O9/c1-11-8-15-19(17(9-11)33-4)14-10-18(34-5)21-16(28)7-6-13(20(21)22(14)36-26(15)31)23-25(30)27(3,32)24(29)12(2)35-23/h6-10,12,23-25,28-30,32H,1-5H3/t12-,23+,24+,25+,27-/m1/s1

InChI key

BJPYMDSMDBCKEP-QSMCFSHASA-N

说明

Biochem/physiol Actions

Antibiotic from Streptomyces sp. Inhibits the catalytic activity of human topoisomerase II.

Antibiotic from Streptomyces sp. Inhibits the catalytic activity of human topoisomerase II. Exhibits antitumor activity against human cell lines K562, HT29, MCF7, PC6, and MKN28.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

124K1396

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Antitumor activity of chrysomycins M and V.

J A Matson et al.

The Journal of antibiotics, 42(9), 1446-1448 (1989-09-01)

Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.

Madan K Kharel et al.

Natural product reports, 29(2), 264-325 (2011-12-22)

Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder

A colorimetric microassay for the detection of agents that interact with DNA.

N S Burres et al.

Journal of natural products, 55(11), 1582-1587 (1992-11-01)

A simple microtiter assay for the detection of compounds that bind DNA is described. Agents that displace methyl green from DNA are detected spectrophotometrically by a decrease in absorbance at 630 nm. The feasibility of using the assay for detecting

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全球贸易项目编号

货号	GTIN
C6491-100UG	04061833384336