Monoclonal Anti-Calmodulin antibody produced in mouse

A preparation of purified calmodulin from Dictyostelium discoideum conjugated to KLH.

Monoclonal Anti-Calmodulin antibody produced in mouse is suitable for microarray and western blotting at a dilution of 1:100 using a bovine brain calmodulin preparation.

These antibodies are directed against different epitopes within the calmodulin molecule.

Calmodulin 1 is a protein encoded by the CALM1 gene in humans. It is one of the most well characterized proteins and is used as a model system for calcium binding and large-scale protein conformational changes. Acts as a sensor protein that takes part in calcium-dependent signaling, regulating processes like growth, differentiation, proliferation and motility. It binds calcium ions during induction of intracellular signaling and is involved in silencing of calcium signal through activation of plasma membrane Ca²⁺-ATPase (directly) or SERCA pump (indirectly). Calmodulin may affect various channels like voltage gated calcium channels (VGCCs), transient receptor potential channels (TRPCs), NMDA receptors and calcium channels dependent on cyclic nucleotides or in endoplasmic reticulum.

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