form
solid
mol wt
apparent mol wt 514.6
General description
Cefpirome is a bactericidal antibiotic, which belongs to the fourth generation of cephalosporins. It shows a broad spectrum of activity against gram positive and gram negative bacteria.
Application
4th generation cephalosporin antibacterial.
Cefpirome may be used as a reference standard in the determination of cefpirome in pharmaceutical formulations and human plasma samples using reversed phase high performance liquid chromatography (RP-HPLC).
Cefpirome may be used as a reference standard in the determination of cefpirome in pharmaceutical formulations and human plasma samples using reversed phase high performance liquid chromatography (RP-HPLC).
C C Wagner et al.
International journal of clinical pharmacology and therapeutics, 47(3), 178-186 (2009-03-14)
Knowledge on the elimination of antibiotics by extracorporeal hemofiltration is a prerequisite for appropriate antimicrobial dosing in patients with renal failure. The present study set out to determine the clearance of the novel lipopetide antibiotic daptomycin from human whole blood
Juliana F Roos et al.
Intensive care medicine, 33(5), 781-788 (2007-03-08)
To develop a population pharmacokinetics model for cefpirome in ICU patients, to assess pharmacokinetic-pharmacodynamic profiles vs. MIC distribution of likely ICU pathogens, and to assess their expected cumulative fraction of response (CFR). Prospective observational study in a multidisciplinary ICU. Twelve
Cristina Tuchiluş et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 110(2), 465-467 (2007-09-07)
Cefpirome and cefepime possess a greater antibacterial spectrum in vitro than third-generation cephalosporins because they are active against Enterobacteriaceae, which produce beta-lactamases, which may inactivate third-generation cephalosporins. The aim of this study was to quantitatively compare the in vitro activity
Alejandro Beceiro et al.
The Journal of antimicrobial chemotherapy, 66(9), 2006-2010 (2011-07-12)
Two clinical isolates of Escherichia coli, EC18 and EC21, were non-susceptible (MICs 4-16 mg/L) to cefpirome and cefepime, with marked synergy with clavulanate, yet were susceptible to cefotaxime and ceftazidime (MICs ≤ 1 mg/L). EC19, from the same patient as
Simultaneous quantification of cefpirome and cetirizine or levocetirizine in pharmaceutical formulations and human plasma by RP-HPLC.
Journal of Analytical Chemistry, 63(9), 881-887 (2008)
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