form
solid
mol wt
apparent mol wt 514.6
General description
Cefpirome is a bactericidal antibiotic, which belongs to the fourth generation of cephalosporins. It shows a broad spectrum of activity against gram positive and gram negative bacteria.
Application
4th generation cephalosporin antibacterial.
Cefpirome may be used as a reference standard in the determination of cefpirome in pharmaceutical formulations and human plasma samples using reversed phase high performance liquid chromatography (RP-HPLC).
Cefpirome may be used as a reference standard in the determination of cefpirome in pharmaceutical formulations and human plasma samples using reversed phase high performance liquid chromatography (RP-HPLC).
Yu Chieh Su et al.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 40(1), 62-67 (2007-03-03)
The objective of this study was to document the clinical experience of cefpirome use in the treatment of febrile neutropenia in everyday medical practice. This was an open, non-controlled multicenter study. Patients with fever and neutropenia were started on cefpirome
John F Graf et al.
Journal of pharmacokinetics and pharmacodynamics, 39(1), 37-54 (2011-12-14)
We developed a detailed, whole-body physiologically based pharmacokinetic (PBPK) modeling tool for calculating the distribution of pharmaceutical agents in the various tissues and organs of a human or animal as a function of time. Ordinary differential equations (ODEs) represent the
J B Bulitta et al.
Antimicrobial agents and chemotherapy, 55(6), 2927-2936 (2011-03-16)
Cystic fibrosis (CF) patients are often reported to have higher clearances and larger volumes of distribution per kilogram of total body weight (WT) for beta-lactams than healthy volunteers. As pharmacokinetic (PK) data on cefpirome from studies of CF patients are
Francis F Arhin et al.
Antimicrobial agents and chemotherapy, 54(8), 3481-3483 (2010-05-26)
Biophysical methods to study the binding of oritavancin, a lipoglycopeptide, to serum protein are confounded by nonspecific drug adsorption to labware surfaces. We assessed oritavancin binding to serum from mouse, rat, dog, and human by a microbiological growth-based method under
Rajeev Jain et al.
Colloids and surfaces. B, Biointerfaces, 87(2), 423-426 (2011-07-05)
A new, simple and low cost voltammetric method for the determination of cefpirome in pharmaceutical preparations has been developed using multiwalled carbon nanotube modified glassy carbon electrode (MWCNT), which showed stable response with enhanced selectivity and sensitivity over the bare
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