C7124
Cryptolepine hydrate
≥98% (HPLC)
别名:
5-Methyl-5H-quindoline hydrate
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关于此项目
经验公式（希尔记法）:
C16H12N2 · xH2O
化学文摘社编号:
分子量:
232.28 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
AOTFRBDOIUZYCT-UHFFFAOYSA-N
SMILES string
O.Cn1c2ccccc2cc3nc4ccccc4c13
InChI
1S/C16H12N2.H2O/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14;/h2-10H,1H3;1H2
assay
≥98% (HPLC)
form
powder
color
purple
solubility
DMSO: ≥5 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
Cryptolepine hydrate is a cytoxic, anti-cancer, antimalarial agent
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
João Lavrado et al.
Journal of medicinal chemistry, 54(3), 734-750 (2011-01-07)
The synthesis of cryptolepine derivatives containing basic side-chains at the C-11 position and their evaluations for antiplasmodial and cytotoxicity properties are reported. Propyl, butyl, and cycloalkyl diamine side chains significantly increased activity against chloroquine-resistant Plasmodium falciparum strains while reducing cytotoxicity
Arnold Donkor Forkuo et al.
BMC pharmacology & toxicology, 18(1), 84-84 (2017-12-24)
This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and intravenous pharmacokinetics of cryptolepine in male
Olumayokun A Olajide et al.
Bioorganic & medicinal chemistry, 15(1), 43-49 (2006-10-27)
The alkaloid cryptolepine is thought to mediate the anti-inflammatory effects of the climbing shrub, Cryptolepis sanguinoleta. The underlying mechanism of action, however, is largely unknown. In the present study, we show that the synthetic cryptolepine-hydrochloride (2.5-10microM) dose-dependently inhibits lipopolysaccharide (LPS)-induced
Yumin Zhang et al.
Frontiers in cellular and infection microbiology, 11, 624745-624745 (2021-03-26)
Human babesiosis is a CDC reportable disease in the United States and is recognized as an emerging health risk in multiple parts of the world. The current treatment for human babesiosis is suboptimal due to treatment failures and unwanted side
Yu-Jing Lu et al.
Chemical communications (Cambridge, England), 47(17), 4971-4973 (2011-03-25)
A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective
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