C7145
Cefamandole sodium salt
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关于此项目
线性分子式:
C18H17N6O5S2Na
化学文摘社编号:
分子量:
484.48
UNSPSC Code:
51101500
PubChem Substance ID:
EC Number:
250-009-0
MDL number:
SMILES string
[Na+].Cn1nnnc1SCC2=C(N3C(SC2)[C@H](NC(=O)[C@H](O)c4ccccc4)C3=O)C([O-])=O
mode of action
cell wall synthesis | interferes
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General description
Chemical structure: β-lactam
Application
Cefamandole is used to study antibiotic resistance, the effects of expression and inhibition of penicillin-binding proteins, and the cooperation of antibiotics with host defence mechanisms .
Cefamandole is used to study the effects of expression and inhibition of PBP 2A and other penicillin-binding proteins (PDPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Cefamandole, a cephalosporin antibiotic, disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. As Cefamandole is broken down in the body, it releases free N-methylthiotetrazole, which can cause hypoprothrombinemia .
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
A Andreana et al.
Antimicrobial agents and chemotherapy, 25(2), 182-186 (1984-02-01)
Our purpose was to study whether treatment of Escherichia coli with subinhibitory concentrations of either cefamandole or gentamicin could change bacterial susceptibility to the serum bactericidal effect and to the phagocytic and killing activity of the rat liver reticuloendothelial system.
Stork CM
Antibiotics, Antifungals, and Antivirals, 847-847 (2006)
T D Gootz et al.
The Journal of infectious diseases, 146(1), 34-42 (1982-07-01)
Studies were performed to characterize resistance to cefamandole in two strains of Enterobacter cloacae. Susceptible wild-type cells were exposed either to cefamandole to select stably resistant mutants or to cefoxitin to induce unstable resistance. The two types of resistant cells
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