Monoclonal Anti-Cytokeratin 4.62 antibody produced in mouse

cytoskeletal proteins from the cultured human breast carcinoma cell line MCF-7

Monoclonal Anti-Cytokeratin 4.62 antibody produced in mouse is suitable for indirect immunofluorescence at a dilution of 1:20 using frozen human tissue sections.

Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.

Reacts with cytokeratin polypeptide 19. The antibody labels the basal layer of non-keratinizing epithelium, metaplastic epithelium of the cervix, simple epithelium, transitional epithelium, squamous cell carcinomas and adenocarcinomas expressing cytokeratin 19.

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