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Merck
CN

C7632

Sigma-Aldrich

斑蝥素

protein phosphatase 2 A (PPA2) inhibitor

别名:

2,3-二甲基-7-氧杂-双环[2.2.1]庚烷-2,3-二羧酸酐, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione, 六氢-3α,7α-二甲基-4,7-环氧异苯并呋喃-1,3-二酮, 班蝥酸酐

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关于此项目

经验公式（希尔记法）:
C10H12O4
化学文摘社编号:
56-25-7
分子量:
196.20
EC 号:
200-263-3
MDL编号:
MFCD00134968
UNSPSC代码:
12352200
PubChem化学物质编号:
24278334
NACRES:
NA.77

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产品名称

斑蝥素,

颜色

white

mp

215-217 °C (lit.)
215-218 °C

溶解性

DMSO: soluble
ethanol: soluble

SMILES字符串

C[C@]12C3CCC(O3)[C@@]1(C)C(=O)OC2=O

InChI

1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-

InChI key

DHZBEENLJMYSHQ-XCVPVQRUSA-N

基因信息

human ... PPP2CA(5515), PPP2CB(5516), PPP2CBP(5517), PPP2R1A(5518), PPP2R1B(5519), PPP2R2A(5520), PPP2R2B(5521), PPP2R2C(5522), PPP2R3A(5523), PPP2R5A(5525)

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相关类别

一般描述

斑蝥素是一种由斑蝥产生的有毒的发泡剂。它用于治疗痔疮、溃疡、毒虫和瘰疬性皮肤结核。它可用作壮阳药、堕胎药和兽用利尿剂。

应用

斑蝥素已被用于抑制蛋白磷酸酶2（PP2A）。

生化/生理作用

蛋白磷酸酶 2A 的抑制剂。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

高风险级别生物产品--毒素类产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM7986
BCCL3516
BCCK0647
BCCJ4895
BCCF1280

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T I Baskin et al.
Plant physiology, 113(2), 493-502 (1997-02-01)
To investigate molecular mechanisms controlling plant morphogenesis, we examined the morphology of primary roots of Arabidopsis thaliana and the organization of cortical microtubules in response to inhibitors of serine/threonine protein phosphatases and kinases. We found that cantharidin, an inhibitor of
Cécile Segonzac et al.
The EMBO journal, 33(18), 2069-2079 (2014-08-03)
Recognition of pathogen-associated molecular patterns (PAMPs) by surface-localized pattern-recognition receptors (PRRs) activates plant innate immunity, mainly through activation of numerous protein kinases. Appropriate induction of immune responses must be tightly regulated, as many of the kinases involved have an intrinsic
Timothy A Hill et al.
Bioorganic & medicinal chemistry, 15(18), 6126-6134 (2007-07-04)
A range of amines was reacted with norcantharidin (2) to provide the corresponding norcantharimides (9-43). Treatment of norcantharidin with allylamine afforded the corresponding allyl-norcantharimide (20) which was amenable to epoxidation (mCPBA, 22) and subsequent ring opening (MeOH/H(+); 23) or alternatively
Ali Thaqi et al.
European journal of medicinal chemistry, 45(5), 1717-1723 (2010-02-16)
Cantharidin (1) and norcantharidin (2) are potent protein phosphatase 1 and 2A inhibitors that also display high levels of anticancer activity against a broad range of tumor cells lines. Surprisingly, Delta-5,6-ethyl norcantharidin (3, cis-tetrahydrofurano[3,4-c]furan-1,3-dione) displays neither phosphatase inhibition nor anticancer
Heat Oscillations Driven by the Embryonic Cell Cycle Reveal the Energetic Costs of Signaling
Rodenfels J, et al.
Developmental Cell (2019)
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商品

ReadyShield Phosphatase and Protease Inhibitor Cocktail FAQ

ReadyShield® phosphatase and protease inhibitor cocktail FAQ for sample protection in a variety of cell types and tissue extracts, including mammalian, plant, and microbial samples. Our ReadyShield® Protease Inhibitor Cocktail is a non-freezing solution that contains inhibitors with a broad specificity for serine, cysteine, acid proteases and aminopeptidases.

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