C7729
抗Caspase 9 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
Anti-APAF-3, Anti-APAF3, Anti-ICE-LAP6, Anti-MCH6, Anti-PPP1R56
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 35-47 kDa (two bands)
种属反应性
human, rat
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:40 using microwave-treated tissue sections of human and rat heart
immunoprecipitation (IP): 10 μg using HeLa mitochondrial RIPA lysate (500 μg)
microarray: suitable
western blot: 1:300 using whole extract of human Jurkat cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CASP9(842)
rat ... Casp9(58918)
一般描述
胱天蛋白酶9抗体通过在兔体内使用N端添加赖氨酸通过戊二醛与钥孔血蓝蛋白 (KLH) 偶联的、人胱天蛋白酶原9氨基酸对应的合成多肽制备而成。胱天蛋白酶9/CASP9（Mch6，ICE-LAP6，APAF3）是胱天蛋白酶2亚家族的一员，与胱天蛋白酶8和10同被归类为启动型胱天蛋白酶。它是一种含半胱氨酸的天冬氨酸特异性蛋白酶，由416个氨基酸组成，其中有13个是半胱氨酸。CASP9位于人染色体1p36.21上。
免疫原
与人天冬氨酸蛋白酶 9（其中的N-末端添加赖氨酸与 KLH 和戊二醛结合） 的氨基酸残基 299-316相对应的合成肽。
生化/生理作用
胱天蛋白酶9/CASP9是鼠类中枢神经系统正常发育中细胞凋亡的必需因子，并在肿瘤发生发展的控制中发挥作用。当细胞凋亡中的主要事件为线粒体功能障碍时，它会发挥启动型胱天蛋白酶的作用。当细胞凋亡中的主要事件为线粒体功能障碍时，胱天蛋白酶9会发挥启动型胱天蛋白酶的作用。胱天蛋白酶9还可被颗粒酶B激活。
外形
溶于0.01M磷酸盐缓冲盐水，pH 7.4，含有1%牛血清白蛋白以及15 mM叠氮化钠。
免责声明
除非我们的目录或随附于产品的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Acidic extracellular pH shifts colorectal cancer cell death from apoptosis to necrosis upon exposure to propionate and acetate, major end-products of the human probiotic propionibacteria
Lan A, et al.
Apoptosis, 12(3), 573-591 (2007)
Dominika Karolczak et al.
Polish journal of pathology : official journal of the Polish Society of Pathologists, 64(3), 196-203 (2013-10-30)
Aging is the process of progressive accumulation of changes over time, which is additionally connected with increasing susceptibility to some diseases and ultimately leads to death. Aging is associated mainly with loss of permanent cells, e.g. in heart, skeletal muscle
Natalia Edison et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(9), 2569-2578 (2012-03-07)
XIAP [X-linked inhibitor of apoptosis (IAP) protein] is the best characterized mammalian caspase inhibitor. XIAP is frequently overexpressed in a variety of human tumors, and genetic inactivation of XIAP in mice protects against lymphoma. Therefore, XIAP is an attractive target
Alessandro de Souza Prestes et al.
Toxicology in vitro : an international journal published in association with BIBRA, 55, 33-42 (2018-11-18)
Methylglyoxal (MG) is a α-dycarbonyl compound derived mainly from glycolysis, whose accumulation is harmful for cells and tissues. Here, we evaluated the cytotoxic effects induced by MG in leukocytes after an acute exposure, measuring as endpoints of toxicity some markers
Analyses of apoptotic regulators CASP9 and DFFA at 1P36. 2, reveal rare allele variants in human neuroblastoma tumours
Abel F, et al.
British Journal of Cancer, 86(4), 596-596 (2002)
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