Anti-phospho-α-B Crystallin (14-25) (pSer¹⁹) antibody produced in rabbit

synthetic phosphopeptide surrounding the region of human α-B crystallin that contains serine 19.

Anti-phospho-α-B Crystallin (14-25) (pSer¹⁹) antibody produced in rabbit

• Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 10μg/mL
• Indirect immunofluorescence at a concentration of 5μg/mL
• Western blotting at a concentration of 0.5μg/mL using human cell extract
• It also used in 1- and 2-D immune blotting analysis.

α-Crystallin B chain is a protein encoded by the CRYAB gene in humans. αB-crystallin (ABC) and HSP27 are most abundant in human tissues. It is predominantly expressed in triple-negative breast cancer (TNBC) and leads to aggressive tumor phenotype. αB-crystallin expression is primary found in breast carcinomas and brain metastases. αB-crystallin is overexpressed or silenced in two different TNBC cell lines. It is a novel regulator of brain metastasis in TNBC and acts as a potential biomarker for drug target in aggressive disease. αB-crystallin and VEGF expressions in human conjunctival squamous cell carcinoma (CSCCs) may play an important role in the pathogenesis. Mutation in the gene is responsible for a number of inherited human disorders, which include cardiomyopathy, skeletal muscle myopathy and cataracts.

Does not detect the unphosphorylated protein.

Lyophilized from phosphate buffered saline, pH 7.4, containing 3% bovine serum albumin and 0.05% sodium azide.

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