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Merck
CN

C7771

Cholera Toxin B subunit

lyophilized powder

别名:

CTB

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UNSPSC Code:
12352200
MDL number:
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InChI key

YDXZSNHARVUYNM-UHFFFAOYSA-N

InChI

1S/C16H13ClF3NO2/c1-2-23-14-6-4-3-5-11(14)15(22)21-10-7-8-13(17)12(9-10)16(18,19)20/h3-9H,2H2,1H3,(H,21,22)

SMILES string

CCOc1ccccc1C(=O)Nc2ccc(Cl)c(c2)C(F)(F)F

form

lyophilized powder

mol wt

~12 kDa

capacity

>30 units/μg, protein antitoxin combining activity (toxoid)(Lowry)

storage temp.

2-8°C

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Biochem/physiol Actions

The cholera toxin B subunit is used for track tracing in neurological research, taking advantage of GM1 ganglioside binding and retrograde transport.
The cholera toxin B subunit is used for track tracing in neurological research, taking advantage of GM1 ganglioside binding and retrograde transport. Tissue culture cells treated with cholera toxin are not killed and tissues of animals do not become necrotic.

Physical form

Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide, and sodium EDTA.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Steven C Hatch et al.
Journal of virology, 83(8), 3496-3506 (2009-02-06)
Interactions of human immunodeficiency virus type 1 (HIV-1) with dendritic cells (DCs) are multifactorial and presumably require nonredundant interactions between the HIV-1 envelope glycoprotein gp120 and molecules expressed on the DC surface that define the cellular fate of the virus
Fu Shi Quan et al.
Journal of virology, 83(9), 4489-4497 (2009-02-13)
The format of influenza virus-like particles (VLPs) as a nonreplicating particulate vaccine candidate is a promising alternative to conventional egg-based vaccines. In this study, we have investigated the detailed kinetics of immune responses and protective efficacy after a single intranasal
Subha Sen et al.
PLoS pathogens, 7(9), e1002229-e1002229 (2011-09-21)
Despite the presence of significant levels of systemic Interferon gamma (IFNγ), the host protective cytokine, Kala-azar patients display high parasite load with downregulated IFNγ signaling in Leishmania donovani (LD) infected macrophages (LD-MØs); the cause of such aberrant phenomenon is unknown.
Huili Li et al.
Molecular cancer, 10, 100-100 (2011-08-23)
The transcription factor, CCAAT enhancer binding protein-β (C/EBPβ), is expressed as several distinct protein isoforms (LAP1, LAP2 and LIP) that have opposing actions in cellular proliferation and differentiation. Increases in the ratio of LIP/LAP are associated with aggressive, metastatic breast

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