C7987
Anti-CIDE-A, C-Terminal antibody produced in rabbit
~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Cell Death-Inducing DFF-like Effector A
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~23 kDa
种属反应性
human
浓度
~0.5 mg/mL
技术
western blot: 1:1,000-1:2,000
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... CIDEA(1149)
免疫原
synthetic peptide corresponding to amino acids 200-217 of human CIDE-A.
应用
Anti-CIDE-A, C-Terminal antibody is suitable for western blot at a dilution of 1:1,000-1:2,000.
生化/生理作用
Apoptosis or Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family proteases. These signals are generated by DNase in chromosomal DNA degradation. CIDE-A and CIDE-B induce DNA fragmentation and activate apoptosis in mammalian cells. The C-terminal region of CIDE-A is necessary and sufficient for killing. DFF45/ICAD is an inhibitor of caspase activated Dnase, DFF40/CAD and has also been shown to inhibit the apoptotic activities of CIDE-A and CIDE-B. The region of CIDE-A with homology to DFF45 located in the N-terminus was required for DFF45 to inhibit CIDE-A induced apoptosis. CIDE-A is expressed in many tissues including brain.
特点和优势
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外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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N Inohara et al.
The EMBO journal, 17(9), 2526-2533 (1998-06-20)
DFF45 is a subunit of the DNA fragmentation factor (DFF) that is cleaved by caspase-3 during apoptosis. However, the mechanism by which DFF45 regulates apoptotic cell death remains poorly understood. Here we report the identification and characterization of two mammalian
Gustavo Abreu-Vieira et al.
Nature communications, 6, 7433-7433 (2015-06-30)
In humans, Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A) is highly but variably expressed in white fat, and expression correlates with metabolic health. Here we generate transgenic mice expressing human Cidea in adipose tissues (aP2-hCidea mice) and show
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