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Merck
CN

C8145

Cefsulodin sodium salt hydrate

third-generation cephalosporin antibiotic

别名:

7-(D-α-Sulfophenylacetamido)ceph-3-em-3-(4′-carbamoylpyridinium)methyl-4-carboxylate sodium salt

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关于此项目

经验公式（希尔记法）:
C22H19N4NaO8S2 · xH2O
化学文摘社编号:
52152-93-9
分子量:
554.53 (anhydrous basis)
NACRES:
NA.85
PubChem Substance ID:
24278340
UNSPSC Code:
51284140
EC Number:
257-692-4
MDL number:
MFCD07793338

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产品名称

Cefsulodin sodium salt hydrate, third-generation cephalosporin antibiotic

InChI key

REACMANCWHKJSM-DWBVFMGKSA-M

InChI

1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1

SMILES string

[Na+].NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S([O-])(=O)=O)C3=O)C([O-])=O)cc1

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

200

相关类别

Application

Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. Cefuslodin is used in CIN (cefsulodin-Irgasan-novobiocin) agar to select for microorganisms such as E. coli. Cefsulodin is a substrate for rat Oatp1a4. It has been used to study multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across the mouse blood-brain barrier.
Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cefsulodin is a cephalosporin. Cephalosporins disrupt cell wall synthesis by inhibiting PBP crosslinking of peptidoglycan.

General description

Chemical structure: β-lactam

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000521269
0000521268
0000521268
0000521269
0000476531

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M A Hornitzky et al.
FEMS microbiology letters, 198(1), 17-22 (2001-04-28)
The prevalence of complex Shiga toxin-producing Escherichia coli (STEC), i.e. STEC containing accessory virulence factors intimin (eaeA) and/or enterohaemorrhagic E. coli haemolysin (ehxA) and their serotypes were determined in diagnostic bovine faecal samples processed during a 3 months period. The
Bianca A Amézquita-López et al.
PloS one, 7(12), e51565-e51565 (2012-12-20)
Shiga toxin-producing Escherichia coli (STEC) are zoonotic enteric pathogens associated with human gastroenteritis worldwide. Cattle and small ruminants are important animal reservoirs of STEC. The present study investigated animal reservoirs for STEC in small rural farms in the Culiacan Valley
A Lehmacher et al.
Applied and environmental microbiology, 64(7), 2449-2453 (1998-07-02)
The presence of a hemolysin-encoding gene, elyA or hlyA, from Shiga toxin-producing Escherichia coli (STEC) was detected by PCR in each of 95 strains tested. PCR products of elyA from human STEC isolates of serovars frequently detected in Germany, such
Danièle Joseleau-Petit et al.
Journal of bacteriology, 189(18), 6512-6520 (2007-06-26)
Growing bacterial L forms are reputed to lack peptidoglycan, although cell division is normally inseparable from septal peptidoglycan synthesis. To explore which cell division functions L forms use, we established a protocol for quantitatively converting a culture of a wild-type
P Di Martino
Chemotherapy, 47(5), 344-349 (2001-09-19)
The effect of subminimal inhibitory concentration (1/2 MIC) of antimicrobial agents on the adherence of fluorescent Pseudomonas to human fibronectin (FN) was investigated by examining two Pseudomonas fluorescens and four Pseudomonas aeruginosa strains. The Escherichia coli (MC1061 and JM109) strains
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