biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 50 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
immunohistochemistry: 2 μg/mL using human heart tissue, western blot: 0.5-1 μg/mL using human spleen tissue lysate
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CX3CR1(1524)
mouse ... Cx3cr1(13051)
rat ... Cx3cr1(171056)
General description
CX3CR1 is a fractalkaine receptor that regulates chemotaxis and adhesion in white blood cells . Impairment of CX3CR1 function has been associated with defects in hippocampal cognition and neuronal plasticity . Cells expressing CX3CR1 receptors inhibit T-cell proliferation and subsequently prevent intestinal inflammation . Anti-CX3CR-1, N-Terminal antibody is specific for CX3CR1 by immunoblotting using human spleen tissue lysate. The antibody also reacts with mouse and rat CX3CR1.
Immunogen
synthetic peptide corresponding to the N-terminal and amino acids 2-21 of human CX3CR1 (V28, CMKBRL1). This sequence differs from mouse and rat by four amino acids.
Application
Anti-CX3CR-1, N-Terminal antibody is suitable for use in immunoblot (approx. 50kDa), western blot (0.5-1 μg/ml) using human spleen lysate) and immunohistochemistry (~2 μg/mL using human heart tissue).
Physical form
Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Frank Ativie et al.
Frontiers in molecular neuroscience, 11, 295-295 (2018-09-14)
Microglia, the resident immune cells of the brain, play important roles in defending the brain against pathogens and supporting neuronal circuit plasticity. Chronic or excessive pro-inflammatory responses of microglia damage neurons, therefore their activity is tightly regulated. Pharmacological and genetic
Elif Kervancioglu Demirci et al.
Cell adhesion & migration, 10(1-2), 189-196 (2016-01-09)
Embryo implantation and subsequent placentation require a fine balanced fetal-maternal cross-talk of hormones, cytokines and chemokines. Amongst the group of chemokines, CX3CL1 (also known as fractalkine) has recently attracted attention in the field of reproductive research. It exists both as
Hisako Kayama et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(13), 5010-5015 (2012-03-10)
Adequate activation of CD4(+) T lymphocytes is essential for host defense against invading pathogens; however, exaggerated activity of effector CD4(+) T cells induces tissue damage, leading to inflammatory disorders such as inflammatory bowel diseases. Several unique subsets of intestinal innate
Justin T Rogers et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(45), 16241-16250 (2011-11-11)
The protective/neurotoxic role of fractalkine (CX3CL1) and its receptor CX3C chemokine receptor 1 (CX3CR1) signaling in neurodegenerative disease is an intricate and highly debated research topic and it is becoming even more complicated as new studies reveal discordant results. It
T Imai et al.
Cell, 91(4), 521-530 (1997-12-09)
Leukocyte trafficking at the endothelium requires both cellular adhesion molecules and chemotactic factors. Fractalkine, a novel transmembrane molecule with a CX3C-motif chemokine domain atop a mucin stalk, induces both adhesion and migration of leukocytes. Here we identify a seven-transmembrane high-affinity
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