C8395
头孢拉啶
≥90.0% (Cephradine, HPLC)
别名:
Cefradin
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关于此项目
经验公式（希尔记法）:
C16H19N3O4S
化学文摘社编号:
分子量:
349.40
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51282517
MDL number:
InChI
1S/C16H19N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
SMILES string
[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C3=CCC=CC3)C(O)=O
InChI key
RDLPVSKMFDYCOR-UEKVPHQBSA-N
assay
≥90.0% (Cephradine, HPLC)
form
powder
solubility
ethanol: practically insoluble 96%, hexane: practically insoluble, water: slightly soluble
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
Quality Level
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General description
Chemical structure: β-lactam
Application
Cefradin was used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Cefradin is a semi-synthetic cephalosporin that inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), such as PBP3, which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. It is effective against Gram-positive and Gram-negative bacteria. Cefradin may also interfere with autolysin inhibitors.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
James R Adams et al.
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Dental infections are associated with a range of serious complications. The orofacial region provides potential spaces in the tissue that infections of dental origin can occupy. We describe the subtemporal extension of a dental infection, the late development of cranial
Antioxidative responses of Pseudomonas fluorescens YZ2 to simultaneous exposure of Zn and Cefradine.
Yan-Bin Xu et al.
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Binary pollution of both heavy metals and antibiotics has received increasing attentions for their joint effects of eco-toxicity and health hazards. To reveal the effects of mixtures of different pollutants on bacterial antioxidant response system, Pseudomonas fluorescens ZY2, a new
Characteristics of Streptococcus pyogenes strains isolated from Chinese children with scarlet fever.
Yunmei Liang et al.
Acta paediatrica (Oslo, Norway : 1992), 97(12), 1681-1685 (2008-08-12)
To analyse the characteristics of Streptococcus pyogenes isolates from Chinese children with scarlet fever. Minimal inhibitory concentration with nine antibiotics was performed on 145 Streptococcus pyogenes isolates acquired from Beijing and Shanghai in 2007. Their macrolide-resistant genes (mefA, ermB and
Muhammad Harris Shoaib et al.
Pakistan journal of pharmaceutical sciences, 21(4), 400-406 (2008-10-22)
To observe and discuss the difference in the pharmacokinetics of cephradine in Pakistani population with the reported data of other ethnic origins. A Single group pharmacokinetic study was conducted having six healthy male volunteers of 20-24 years of age. Blood
Rhinoscleroma: case report.
Qi Zhong et al.
American journal of otolaryngology, 31(5), 381-383 (2009-12-18)
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