Monoclonal Anti-CD22 antibody produced in mouse

CD22 belongs to the immunoglobulin superfamily. It is expressed on the surface of mature B cells and in the cytoplasm of virtually all B cells but not plasma cells. CD22 is strongly expressed in hairy cell leukemia cells.

hairy cell leukemia cells.

Recognizes the CD22, 135 kDa transmembrane phosphoglycoprotein. The antibody may be used for detection of both membrane and cytoplasmic CD22 and is suitable for flow cytometry and for staining of acetone-fixed, frozen tissue sections. It binds to an epitope dependent on the presence of both the first and the second Ig-like domains of the CD22 molecule. It does not inhibit CD22 mediated adhesion of various cells to CD22 transfected lines.
5th Workshop: Code No. CD22.14.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

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