C8653
Conotoxin GI
≥97% (HPLC)
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关于此项目
经验公式（希尔记法）:
C55H80N20O18S4
化学文摘社编号:
分子量:
1437.61
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCC(O)=O)C(=O)N3)NC1=O)C(N)=O
assay
≥97% (HPLC)
storage temp.
−20°C
Gene Information
human ... TAC1(6863), TACR1(6869)
mouse ... TAC1(21333), TACR1(21336)
rat ... TAC1(24806), TACR1(24807)
Biochem/physiol Actions
Postsynaptic inhibitor at the neuromuscular junction
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J D Ashcom et al.
The Biochemical journal, 328 ( Pt 1), 245-250 (1998-01-10)
The venoms of predatory marine cone snails, Conus species, contain numerous peptides and proteins with remarkably diverse pharmacological properties. One group of peptides are the alpha-conotoxins, which consist of 13-19 amino acids constrained by two disulphide bonds. A biologically active
H Gouda et al.
Biochimica et biophysica acta, 1343(2), 327-334 (1998-01-20)
The conformation of alpha-conotoxin MI, a potent antagonist of the nicotinic acetylcholine receptor, has been investigated in aqueous solution. Two-dimensional NMR experiments and simulated annealing calculations provide the overall topology of alpha-conotoxin MI; then molecular dynamics simulation with the explicit
Gábor Mezö et al.
Methods in molecular biology (Clifton, N.J.), 298, 63-76 (2005-07-27)
Chimeric peptides are unnatural constructs consisting of bioactive compounds from at least two different peptide(s) and/or protein(s) or two sequences from different parts of the same protein. Such multifunctional peptide combinations are prepared to enhance the biological activity or selectivity
Jon Bondebjerg et al.
Chembiochem : a European journal of chemical biology, 4(2-3), 186-194 (2003-03-05)
A bicyclic thioether analogue of alpha-conotoxin G1, a neurotoxin found in the venom of cone snails, was synthesized on solid phase. Two successive intramolecular on-bead cyclizations between a cysteine residue and a chloroacetylated reduced peptide bond are the key steps
Nan Jiang et al.
The journal of physical chemistry. B, 114(34), 11241-11250 (2010-08-07)
The roles of the disulfide bridge, electrostatics, and hydrophobic/hydrophilic effects in the structural stability and conformational changes of six single-disulfide analogues of alpha-conotoxin GI(2-7;3-13) in aqueous solution are investigated by using molecular dynamics simulations with a fragment-based polarization model (J.
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