C8990
Sp-8-pCPT-cAMPS
≥98% (HPLC), solid
别名:
8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic monophosphorothioate, Sp-isomer sodium salt
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C16H14ClN5O5PS2Na
化学文摘社编号:
分子量:
509.86
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
≥98% (HPLC)
表单
solid
包装
vial of 5 μmol
溶解性
H2O: >1 mg/mL
运输
dry ice
储存温度
−70°C
SMILES字符串
[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12
一般描述
Sp-8-pCPT-cAMPS is a nonhydrolyzable analog of cAMP with a p-chlorophenylthio moiety.
应用
Sp-8-pCPT-cAMPS has been used as an agonist for protein kinase A. It has also been used in the inhibition of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) in oligosphere cultures.
生化/生理作用
Selective cAMP-dependent protein kinase (PKA) activator.
Sp-8-pCPT-cAMPS impairs PIP2 production by phosphatidylinositol 4-phosphate 5-kinase (PIP5K) inhibition. It may be involved in promoting remyelination in astrocytes and neurons. The lipophilicity feature of Sp-8-pCPT-cAMPS aids its cell entry for mediating remyelination. It may play a role in lowering Leishmania proliferation in in vitro studies.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Amrita Saha et al.
Frontiers in pharmacology, 11, 782-782 (2020-07-17)
With the identification of novel cAMP binding effector molecules in Trypanosoma, the role of cAMP in kinetoplastida parasites gained an intriguing breakthrough. Despite earlier demonstrations of the role of cAMP in the survival of Leishmania during macrophage infection, there is
Hyun Kyoung Lee et al.
Neuron, 85(6), 1227-1243 (2015-03-11)
Wnt signaling plays an essential role in developmental and regenerative myelination of the CNS; however, contributions of proximal regulators of the Wnt receptor complex to these processes remain undefined. To identify components of the Wnt pathway that regulate these processes
Chunyu Zeng et al.
Journal of hypertension, 27(5), 1033-1041 (2009-03-19)
Vascular smooth muscle cell (VSMC) proliferation is central to the development of vascular diseases, including hypertension, which is regulated by numerous hormones and humoral factors. Our previous study showed that the stimulatory effect of norepinephrine on VSMC proliferation is inhibited
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持