C9246
Anti-CPB1 (361-375) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-CPB1 Carboxypeptidase B precursor, Anti-PASP, Anti-PCPB
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~47 kDa
species reactivity
human
technique(s)
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CPB1(1360)
General description
Carboxypeptidase B1 releases a C-terminal lysine or arginine amino acid preferentially.
Immunogen
synthetic peptide corresponding to amino acids 361-375 of human CPB1
Application
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CPB1 (361-375) antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500 to 1:2000.
Biochem/physiol Actions
Carboxypeptidase B1 is a pancreatic tissue specific metallo-protein and is a marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
K K Yamamoto et al.
The Journal of biological chemistry, 267(4), 2575-2581 (1992-02-05)
A human pancreas-specific protein (PASP), previously characterized as a serum marker for acute pancreatitis and pancreatic graft rejection, has been identified as pancreatic procarboxypeptidase B (PCPB). cDNAs encoding PASP/PCPB were isolated from a human pancreas cDNA library using a combination
Phillip Smethurst et al.
Neurobiology of disease, 96, 236-247 (2016-10-19)
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND), and >95% of familial and sporadic cases involve the deposition of insoluble aggregated, phosphorylated and cleaved TDP-43 protein. Accumulating clinical and biological evidence now indicates that
Saurabh Chatterjee et al.
Journal of immunology (Baltimore, Md. : 1950), 183(6), 4055-4066 (2009-09-01)
LPS-induced sepsis results in oxidative modification and inactivation of carboxypeptidase B1 (CPB1). In this study, immunoprecipitated CPB1 was probed for tyrosine nitration using monoclonal nitrotyrosine-specific Abs in a murine model of LPS-induced sepsis. Tyrosine nitration of CPB1 was significantly reduced
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