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Merck
CN

C9270

Sigma-Aldrich

香豆霉素 A1

别名:

Notomycin A1

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关于此项目

经验公式（希尔记法）:
C55H59N5O20
化学文摘社编号:
4434-05-3
分子量:
1110.08
Beilstein:
470805
MDL编号:
MFCD00057312
UNSPSC代码:
51102829
PubChem化学物质编号:
329775201
NACRES:
NA.85

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表单

powder

溶解性

DMSO: 50 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

DNA synthesis | interferes
enzyme | inhibits

SMILES字符串

CO[C@@H]1[C@@H](OC(=O)c2ccc(C)[nH]2)[C@@H](O)[C@H](Oc3ccc4C(O)=C(NC(=O)c5c[nH]c(C(=O)NC6=C(O)c7ccc(O[C@@H]8OC(C)(C)[C@H](OC)[C@@H](OC(=O)c9ccc(C)[nH]9)[C@H]8O)c(C)c7OC6=O)c5C)C(=O)Oc4c3C)OC1(C)C

InChI

1S/C55H59N5O20/c1-21-12-16-29(57-21)48(67)77-42-38(63)52(79-54(6,7)44(42)71-10)73-31-18-14-26-36(61)34(50(69)75-40(26)24(31)4)59-46(65)28-20-56-33(23(28)3)47(66)60-35-37(62)27-15-19-32(25(5)41(27)76-51(35)70)74-53-39(64)43(45(72-11)55(8,9)80-53)78-49(68)30-17-13-22(2)58-30/h12-20,38-39,42-45,52-53,56-58,61-64H,1-11H3,(H,59,65)(H,60,66)/t38-,39-,42+,43+,44-,45-,52-,53-/m1/s1

InChI key

WTIJXIZOODAMJT-DHFGXMAYSA-N

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一般描述

Chemical structure: coumarin-glycoside

应用

Coumermycin A1 is an aminocoumarin antibiotic used to study processes such as DNA replication, transcription, and recombination that involve DNA topoisomerase II activity. It has been used to treat Staphylococcus aureus endocarditis in the rat model and to study the effect of coumermycin A1 on the expression of 67 fusions in Salmonella typhimurium. .

生化/生理作用

Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.

其他说明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBZ7154
SLBT5569
SLBN6743V
SLBC8762V
061M1846V

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Nucleic acids research, 34(10), 3128-3138 (2006-06-08)
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The last stages of assembly of the aminocoumarin antibiotics, clorobiocin and coumermycin A(1), which target the GyrB subunits of bacterial DNA gyrase, involve enzymatic transfer of the pyrrolyl-2-carbonyl acyl group from a carrier protein (CloN1/CouN1) to the 3'-OH of the
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