C9405
Z-D-Phe-Phe-Gly
≥97% (TLC)
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关于此项目
经验公式（希尔记法）:
C28H29N3O6
化学文摘社编号:
分子量:
503.55
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
OC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)OCc3ccccc3
assay
≥97% (TLC)
storage temp.
−20°C
Biochem/physiol Actions
Virus replication inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
R M Epand et al.
The Journal of biological chemistry, 262(4), 1526-1529 (1987-02-05)
Cyclosporin A, benzyloxycarbonyl-D-Phe-L-Phe-Gly, and amantadine inhibit the dilution of fluorescently labeled lipids, as measured with the resonance energy exchange assay for membrane fusion. The fusion was studied using sonicated vesicles containing 1,2-dioleoyl-sn-glycero(3)phosphoethanolamine, egg (3-sn-phosphatidyl)choline, and cholesterol in a 1:1:1.3 molar
P L Yeagle et al.
Biochemistry, 31(12), 3177-3183 (1992-03-31)
The mechanism by which the hydrophobic peptide Z-D-Phe-L-PheGly inhibits membrane fusion was investigated. Differential scanning calorimetry, 2H nuclear magnetic resonance (NMR), and 13C NMR of phosphatidylcholine bilayers in the presence of Z-D-Phe-L-PheGly indicate that this hydrophobic peptide penetrates the phospholipid
P L Yeagle et al.
Biochemistry, 32(45), 12197-12202 (1993-11-16)
The influence of the antiviral peptide, carbobenzoxy-D-phenylalanyl-L-phenylalanylglycine (ZfFG), on the average conformation of phosphatidylcholine in hydrated bilayers was investigated with multinuclear solid state magnetic resonance (NMR). Phosphatidylcholine was specifically deuterated (separately) in the choline N-methyls, the alpha and beta positions
Malcolm J M Darkes et al.
Biochimica et biophysica acta, 1561(1), 119-128 (2002-05-04)
The effects of two fusion inhibitors on the lipid polymorphism of N-methylated dioleoylphosphatidylethanolamine were studied using temperature-resolved, small-angle X-ray diffraction. The inhibitory role of the tri-peptide carbobenzoxy-D-phenylalanine-L-phenylalanine-glycine and the lipid 1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine in the fusion pathway was studied, using the non-lamellar
M Z Siddiqui
International journal of biological macromolecules, 26(1), 17-21 (1999-10-16)
Few dehydrophenylalanine (deltaPhe) analogues (X-deltaPhe-Phe-Gly-X1, X = Ac-; Boc-; Z-; X1 = OMe; OH; ONH2) of virus replication inhibiting peptide (Z-D-Phe-Phe-Gly) were synthesized, and their solution conformations were investigated by 1H NMR, UV and circular dichroism (CD) spectroscopy. Homogeneity of
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