C9635
DL-p-氯苯异丙胺 盐酸盐
≥94% (HPLC)
别名:
PCA
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关于此项目
线性分子式:
ClC6H4CH2CH(CH3)NH2·HCl
化学文摘社编号:
分子量:
206.11
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352103
MDL number:
InChI
1S/C9H12ClN.ClH/c1-7(11)6-8-2-4-9(10)5-3-8;/h2-5,7H,6,11H2,1H3;1H
SMILES string
Cl.CC(N)Cc1ccc(Cl)cc1
InChI key
DZAANUYJOGCNLL-UHFFFAOYSA-N
assay
≥94% (HPLC)
form
powder
drug control
Home Office Schedule 1; regulated under CDSA - not available from Sigma-Aldrich Canada
color
white to off-white
mp
168-170 °C (lit.)
solubility
DMSO: >20 mg/mL, H2O: >20 mg/mL
storage temp.
−20°C
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Biochem/physiol Actions
Neurotoxic on prolonged administration or at high dosage; substrate for the serotonin transporter that releases serotonin from axon terminals by a nonexocytotic mechanism and blocks the reuptake of serotonin; inhibits tryptophan hydroxylase.
signalword
Danger
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT RE 2 - STOT SE 3
target_organs
Brain, Central nervous system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
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P Scholze et al.
The Journal of pharmacology and experimental therapeutics, 293(3), 870-878 (2000-06-28)
HEK 293 cells stably expressing the human serotonin transporter (hSERT) were grown on coverslips, preincubated with [(3)H]5-hydroxytryptamine (5-HT), and superfused. Substrates of the hSERT [e.g., p-chloroamphetamine (PCA)], increased the basal efflux of [(3)H]5-HT in a concentration-dependent manner. 5-HT reuptake blockers
Takumi Oti et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Male sexual function in mammals is controlled by the brain neural circuits and the spinal cord centers located in the lamina X of the lumbar spinal cord (L3-L4). Recently, we reported that hypothalamic oxytocin neurons project to the lumbar spinal
Joke Baute et al.
Genome biology, 16, 168-168 (2015-09-12)
To sustain the global requirements for food and renewable resources, unraveling the molecular networks underlying plant growth is becoming pivotal. Although several approaches to identify genes and networks involved in final organ size have been proven successful, our understanding remains
Sander Biesbroek et al.
The American journal of clinical nutrition, 102(1), 146-154 (2015-05-15)
Several methods are used to determine dietary patterns. Hybrid methods incorporate information on nutrient intake or biological factors to extract patterns relevant to disease etiology. We explore differences between patterns derived with 2 hybrid methods with those obtained by a
H Harrington Cleveland et al.
Development and psychopathology, 27(1), 51-67 (2015-02-03)
Data drawn from the in-home subsample of the PROSPER intervention dissemination trial were used to investigate the moderation of intervention effects on underage alcohol use by maternal involvement and candidate genes. The primary gene examined was dopamine receptor D4 (DRD4).
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