CAMK2α is a ser/thr protein kinase that is a member of the Ca²⁺/calmodulin-dependent protein kinase family. CAMK2α is abundant in the brain as a major constituent of the postsynaptic density and is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its CaCa²⁺/calmodulin-dependent activity, CAMK2α can undergo autophosphorylation, resulting in Ca²⁺/calmodulin-independent activity. The protein level of CAMK2α fluctuates during neuronal activity in cultured rat pup hippocampal neurons. The levels of CAMK2α increased with heightened neuronal activity.

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