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Merck
CN

D0160

16,16-二甲基前列腺素 E2

methyl acetate solution

别名:

16,16-二甲基-PGE2

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关于此项目

经验公式(希尔记法):
C22H36O5
化学文摘社编号:
分子量:
380.52
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
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biological source

synthetic (organic)

assay

≥98% (HPLC)

form

methyl acetate solution

concentration

10 mg/mL

functional group

carboxylic acid

lipid type

unsaturated FAs

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O

InChI

1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,19-,20-/m1/s1

InChI key

QAOBBBBDJSWHMU-WMBBNPMCSA-N

Preparation Note

恢复由于冷冻而沉淀的溶液可能需要激越或短暂的超声处理。可以使用N2或真空除去乙酸甲酯。可以制备1-5 mg/mL的无水酒精储备溶液,并用等渗盐水稀释。

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

8.6 °F

flash_point_c

-13 °C

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

危险化学品

此项目有


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Tomonori Kunikata et al.
Digestive diseases and sciences, 47(4), 894-904 (2002-05-07)
We evaluated the effect of various PGE analogs specific to EP receptor subtypes on indomethacin-induced small intestinal lesions in rats and investigated the relationship of EP receptor subtype with the PGE action using EP receptor knockout mice. Animals were administered
Sara S Roscioni et al.
British journal of pharmacology, 162(1), 193-209 (2010-09-02)
Changes in airway smooth muscle (ASM) phenotype may contribute to the pathogenesis of airway disease. Platelet-derived growth factor (PDGF) switches ASM from a contractile to a proliferative, hypo-contractile phenotype, a process requiring activation of extracellular signal-regulated kinase (ERK) and p70(S6)
Corey Cutler et al.
Blood, 122(17), 3074-3081 (2013-09-03)
Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count
Felicita E Baratelli et al.
Journal of immunology (Baltimore, Md. : 1950), 173(9), 5458-5466 (2004-10-21)
Dendritic cell (DC) migration is crucial for the initiation of immune responses. The balance between metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) has been shown to modulate DC migration. PGE2, which is overproduced in a wide variety of human
Kikuko Amagase et al.
Journal of gastroenterology and hepatology, 25 Suppl 1, S111-S118 (2010-07-14)
We examined the effect of lafutidine, a histamine H(2) receptor antagonist with a mucosal protective action mediated by capsaicin-sensitive sensory neurons (CSN), on intestinal lesions produced by loxoprofen administration in rats. Animals were given loxoprofen (10-100 mg/kg p.o.) and killed

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货号GTIN
D0160-1MG04061838063571

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