D045
1-甲基-4-苯基-1,2,3,6-四氢吡啶 盐酸盐
别名:
MPTP 盐酸盐
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经验公式（希尔记法）:
C12H15N · HCl
化学文摘社编号:
分子量:
209.72
Beilstein:
3707312
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
SMILES字符串
Cl[H].CN1CCC(=CC1)c2ccccc2
InChI
1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChI key
KOWJANGMTAZWDT-UHFFFAOYSA-N
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生化/生理作用
多巴胺能神经毒素。
免责声明
据报道可在人和猴中导致严重且不可逆转的帕金森症状。
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J D Elsworth et al.
Experimental neurology, 211(1), 252-258 (2008-03-19)
Neural transplantation offers the potential of treating Parkinson's disease by grafting fetal dopamine neurons to depleted regions of the brain. However, clinical studies of neural grafting in Parkinson's disease have produced only modest improvements. One of the main reasons for
Fei Sa et al.
Neuroscience letters, 593, 7-12 (2015-03-17)
Dibenzocyclooctadiene lignans represent a unique group of natural chemical structures, are considered as protectants against neuronal cell death and cognitive impairment in neurological disorders. Among the family of dibenzocyclooctadiene lignan analogs from the fruit of Schisandra chinensis (Turcz.) Baill, neuroprotective
Milena Cannella et al.
Neuropharmacology, 95, 50-58 (2015-03-10)
Neuroadaptive changes involving the indirect pathway of the basal ganglia motor circuit occur in the early phases of parkinsonism. The precise identification of these changes may shed new light into the pathophysiology of parkinsonism and better define the time window
Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease.
WeiZhen Liu et al.
European journal of pharmacology, 765, 284-290 (2015-08-25)
Oxyntomodulin is a hormone and a growth factor. It activates two receptors, the Glucagon-like peptide 1 (GLP-1) and the glucagon receptor. GLP-1 mimetics are on the market as treatments for type 2 diabetes and are well tolerated. These drugs have
Philippe Huot et al.
Neuropharmacology, 82, 76-87 (2014-01-23)
L-3,4-Dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease (PD), but its long-term administration is complicated by wearing-off and dyskinesia. UWA-101, a dual, equipotent inhibitor of dopamine (DAT) and serotonin (SERT) transporters, has previously been shown to successfully extend
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