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D0569

DT-3 三氟乙酸盐

Name: DT-3 三氟乙酸盐
Brand: SIGMA

≥95% (HPLC), lyophilized powder

别名:

Drosophila Antennapedia homeodomain (43-58)

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关于此项目

经验公式（希尔记法）:

C₁₅₂H₂₅₉N₅₃O₂₇S · xC₂HF₃O₂

化学文摘社编号:

329306-46-9

分子量:

3293.09 (free base basis)

UNSPSC Code:

12352200

MDL number:

MFCD11114382

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属性

assay

≥95% (HPLC)

form

lyophilized powder

composition

Peptide content, ~64%

color

white

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc6c[nH]cn6)C(N)=O

说明

Biochem/physiol Actions

Cell permeable cGMP-dependent protein kinase type Ia (PKG) inhibitor

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

087K4706

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Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart.

Thomas Krieg et al.

American journal of physiology. Heart and circulatory physiology, 288(4), H1976-H1981 (2004-12-14)

Bradykinin and acetylcholine (ACh) trigger preconditioning by ATP-sensitive K(+) (K(ATP)) channel-dependent production of reactive oxygen species (ROS). Recent evidence suggests that ROS production may in turn be influenced by cGMP-dependent protein kinase (PKG). This study utilized DT-2 and DT-3 peptides

Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ia inhibit NO-induced cerebral dilation

Dostmann, Wolfgang R.G. et al.

Proceedings of the National Academy of Sciences of the USA, 19, 14772 - 14777 (2000)

Exploring the mechanisms of vascular smooth muscle tone with highly specific, membrane-permeable inhibitors of cyclic GMP-dependent protein kinase Ialpha.

Wolfgang R G Dostmann et al.

Pharmacology & therapeutics, 93(2-3), 203-215 (2002-08-23)

The structural similarity of cyclic GMP-dependent protein kinase (cGPK) and cyclic AMP-dependent protein kinase (cAPK) has made it difficult to study cGPK pathways independent of those mediated by cAPK, primarily due to the lack of potent and selective cGPK inhibitors.