D0758
2′-Deoxyinosine 5′-triphosphate trisodium salt
synthetic, 95-97%
别名:
dITP-Na3
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关于此项目
经验公式（希尔记法）:
C10H12N4Na3O13P3
化学文摘社编号:
分子量:
558.11
UNSPSC Code:
41106305
PubChem Substance ID:
EC Number:
306-018-8
MDL number:
InChI key
FHYSVBOUQFJKCI-PWDLANNDSA-K
InChI
1S/C10H15N4O13P3.3Na/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;;/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19);;;/q;3*+1/p-3/t5-,6+,7+;;;/m0.../s1
SMILES string
[Na+].[Na+].[Na+].O[C@H]1C[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)n2cnc3C(=O)NC=Nc23
biological source
synthetic
assay
95-97%
shipped in
dry ice
storage temp.
−20°C
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Application
2′-Deoxyinosine 5-triphosphate (dITP) may be formed by nitrosative deamination processes such as those that deaminate adenosine in DNA and RNA. dITP may be useful in studies of this process.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Gel compressions and artifact banding can be resolved in the same DNA sequence reaction.
K W McCrea et al.
BioTechniques, 15(5), 843-844 (1993-11-01)
ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells.
Sakumi K, Abolhassani N, et al.
Mutation Research, 703, 4-50 (2010)
T Auer et al.
Nucleic acids research, 24(24), 5021-5025 (1996-12-15)
The ability to selectively amplify RNA in the presence of genomic DNA of analogous sequence is cumbersome and requires implementation of critical controls for genes lacking introns. The convenient approaches of either designing oligonucleotide primers at the splice junction or
Random mutagenesis by using mixtures of dNTP and dITP in PCR.
O P Kuipers
Methods in molecular biology (Clifton, N.J.), 57, 351-356 (1996-01-01)
Zun Wang et al.
Molecular biotechnology, 53(1), 49-54 (2012-02-22)
An alternative method to combine mutagenesis PCR with dITP and fragmentation by endonuclease V for directed evolution was developed. In comparison to the routine protocol for directed evolution, dITP was used as mutation reagent in the mutagenesis PCR. Subsequently, the
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