Merck
CN

D1413

Sigma-Aldrich

2′,3′-二脱氢-3′-脱氧胸苷

≥98% (TLC)

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别名:
Stavudine
Empirical Formula (Hill Notation):
C10H12N2O4
CAS号:
分子量:
224.21
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (TLC)

形式

powder

储存温度

−20°C

SMILES string

CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O

InChI

1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1

InChI key

XNKLLVCARDGLGL-JGVFFNPUSA-N

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此商品
Y00004211620209Y0000408
Stavudine for system suitability European Pharmacopoeia (EP) Reference Standard

Y0000421

司他夫定

Stavudine European Pharmacopoeia (EP) Reference Standard

Y0000408

司他夫定

form

powder

form

-

form

-

form

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

一般描述

2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase.

应用

2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment. It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity. It has also been used in the preclinical evaluation of GS-9160.

生化/生理作用

2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus.

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Slide 1 of 1

1 of 1

Stephen Arpadi et al.
Archives of disease in childhood, 98(4), 258-264 (2012-12-12)
Few studies have assessed metabolic and body composition alterations in perinatally HIV-infected African children on antiretroviral therapy (ART). We compared metabolic profiles and regional fat of children on ritonavir-boosted lopinavir (lopinavir/ritonavir), lamivudine and stavudine to those switched to nevirapine, lamivudine
Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometry
Cossarizza A, et al.
Nature Protocols, 4(12), 1790-1790 (2009)
Caenorhabditis elegans as a model system for studying drug induced mitochondrial toxicity
de Boer R, et al.
PLoS ONE, 10(5), e0126220-e0126220 (2015)
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase
Jones G S, et al.
Antimicrobial Agents and Chemotherapy, 53(3), 1194-1203 (2009)
Nittaya Phanuphak et al.
Antiviral therapy, 17(8), 1521-1531 (2012-12-12)
Due to superior long-term toxicity profiles, zidovudine (AZT) and tenofovir disoproxil fumarate (TDF) are preferred over stavudine (d4T) for first-line antiretroviral regimens. However, short-term d4T use could be beneficial in avoiding AZT-induced anaemia. We randomized (1:1:1) 150 treatment-naive Thai HIV-infected

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