D1446
右丙亚胺
≥95% (HPLC), cardiopulmonary protectant, powder
别名:
(+)-(S)-4,4′-丙烯二-2,6-哌嗪二酮, ICRF-187, NSC169780, Zinecard, 心氧烷, （S）-（+）-1,2-双（3,5-二氧杂哌嗪-1-基）丙烷
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关于此项目
经验公式（希尔记法）:
C11H16N4O4
化学文摘社编号:
分子量:
268.27
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
产品名称
右丙亚胺, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >20 mg/mL
originator
Johnson & Johnson
storage temp.
room temp
SMILES string
C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
InChI
1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
InChI key
BMKDZUISNHGIBY-ZETCQYMHSA-N
General description
Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.
Application
Dexrazoxane has been used in chromatin remodelling experiments.
Biochem/physiol Actions
右雷佐生是一种心脏保护化合物，用于抵消蒽环类药物的作用。右雷佐生被认为是一种自由基清除剂。
右雷佐生是抗蒽环类的心脏保护化合物。它通过抑制拓扑异构酶 II 而起作用，而不会引起 DNA 链断裂。右雷佐生是丙亚胺的 + 对映异构体。
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable