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D1446

右丙亚胺

Name: 右丙亚胺
Brand: SIGMA

≥95% (HPLC), cardiopulmonary protectant, powder

别名:

(+)-(S)-4,4′-丙烯二-2,6-哌嗪二酮, ICRF-187, NSC169780, Zinecard, 心氧烷, （S）-（+）-1,2-双（3,5-二氧杂哌嗪-1-基）丙烷

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关于此项目

经验公式（希尔记法）:

C₁₁H₁₆N₄O₄

化学文摘社编号:

24584-09-6

分子量:

268.27

UNSPSC Code:

12352200

PubChem Substance ID:

329798699

NACRES:

NA.77

MDL number:

MFCD00866449

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

右丙亚胺, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

InChI

1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1

InChI key

BMKDZUISNHGIBY-ZETCQYMHSA-N

说明

General description

Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.

Application

Dexrazoxane has been used in chromatin remodelling experiments.

Biochem/physiol Actions

右雷佐生是一种心脏保护化合物，用于抵消蒽环类药物的作用。右雷佐生被认为是一种自由基清除剂。

右雷佐生是抗蒽环类的心脏保护化合物。它通过抑制拓扑异构酶 II 而起作用，而不会引起 DNA 链断裂。右雷佐生是丙亚胺的 + 对映异构体。

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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商品

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

Plasmodium falciparum and Plasmodium yoelii: Effect of the Iron Chelation Prodrug Dexrazoxane onin VitroCultures

Loyevsky M, et al.

Experimental Parasitology, 91(2), 105-114 (1999)

Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin's disease

Tebbi CK, et al.

Journal of Clinical Oncology, 25(5), 493-500 (2007)

Dexrazoxane use in pediatric patients with acute lymphoblastic or myeloid leukemia from 1999 and 2009: analysis of a national cohort of patients in the Pediatric Health Information Systems database.

Dana M Walker et al.

Pediatric blood & cancer, 60(4), 616-620 (2012-09-06)

Acute lymphoblastic (ALL) and myeloid leukemia (AML) account for approximately 26% of pediatric cancers. Anthracyclines are widely used to treat these leukemias, but dosing is limited by cardiotoxicity. Data support the efficacy of dexrazoxane as a cardioprotectant in children; however

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全球贸易项目编号

货号	GTIN
D1446-25MG	04061833024041
D1446-5MG	04061833024058