D1694
Anti-DYRK1A (N-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Dual-specificity tyrosine-phosphorylation-regulated kinase 1A, Anti-MBN/MNBH, Anti-MNB protein kinase, Anti-Minibrain Drosophila homolog
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
western blot
western blot
Species reactivity:
rat, mouse, human
Citations:
12
Technique(s):
western blot: 1.5-3 μg/mL using rat brain embryonic extract (S1 fraction)
western blot: 3-5 μg/mL using PC12 cell lyste
western blot: 3-5 μg/mL using PC12 cell lyste
Uniprot accession no.:
产品名称
Anti-DYRK1A (N-terminal) antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~86 kDa
species reactivity
rat, mouse, human
concentration
~1.5 mg/mL
technique(s)
western blot: 1.5-3 μg/mL using rat brain embryonic extract (S1 fraction)
western blot: 3-5 μg/mL using PC12 cell lyste
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DYRK1A(1859)
mouse ... Dyrk1a(13548)
rat ... Dyrk1a(25255)
Application
Anti-DYRK1A (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.
Biochem/physiol Actions
DYRK1A is encoded by a gene located within the Down syndrome (DS) critical region on human chromosome 21 and its expression is found to be elevated in individuals with DS. It might be one of the genes involved in some of the neurological abnormalities observed in DS. It phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
DYRK1A (N-terminal) encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-c
DYRK1A (dual-specificity tyrosine-phosphorylated regulated kinase 1A) is a member of a growing family of Ser/Thr protein kinases termed DYRKs.
The human and rodent DYRK1A are ubiquitously expressed in adult and fetal tissue with high expression in the brain and heart during development.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
法规信息
常规特殊物品
此项目有
Protein profile and morphological alterations in penumbra after focal photothrombotic infarction in the rat cerebral cortex
Uzdensky A, et al.
Molecular Neurobiology, 54(6), 4172-4188 (2017)
Manon Moreau et al.
Biomedicines, 10(6) (2022-06-25)
Down syndrome (DS) is a complex genetic condition due to an additional copy of human chromosome 21, which results in the deregulation of many genes. In addition to the intellectual disability associated with DS, adults with DS also have an
Benoît Souchet et al.
Acta neuropathologica communications, 7(1), 46-46 (2019-03-20)
Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer's disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in AD patients hippocampus without consequences on its kinase activity. Resulting truncated forms
Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice
Fotaki V, et al.
Molecular and cellular biology, 22(18), 6636-6647 (2002)
Mark Meyers et al.
The Journal of biological chemistry, 280(7), 5516-5526 (2004-12-22)
Previous studies from our laboratory indicated that expression of the MLH1 DNA mismatch repair (MMR) gene was necessary to restore cytotoxicity and an efficient G(2) arrest in HCT116 human colon cancer cells, as well as Mlh1(-/-) murine embryonic fibroblasts, after
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