D1814
Anti-DcR3 antibody produced in rabbit
~0.5 mg/mL, IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-Decoy Receptor 3, Anti-TNFRSF6B, Anti-TR6
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关于此项目
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, WB
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 33 kDa
species reactivity
mouse, rat, human
concentration
~0.5 mg/mL
technique(s)
microarray: suitable, western blot: 1:500-1:1,000 using human heart, brain or kidney lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TNFRSF6B(8771)
mouse ... Dcr3(497118)
General description
It is a member of the tumor necrosis factor receptor superfamily (TR6). DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.
Immunogen
synthetic peptide corresponding to amino acids 31-46 of human DcR3 precursor.
Application
Anti-DcR3 antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:1000 using human heart, brain or kidney lysates.
Biochem/physiol Actions
DcR3 is a soluble decoy receptor that binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis.
Physical form
Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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R M Pitti et al.
Nature, 396(6712), 699-703 (1999-01-01)
Fas ligand (FasL) is produced by activated T cells and natural killer cells and it induces apoptosis (programmed cell death) in target cells through the death receptor Fas/Apol/CD95. One important role of FasL and Fas is to mediate immune-cytotoxic killing
K Y Yu et al.
The Journal of biological chemistry, 274(20), 13733-13736 (1999-05-13)
TR6 (decoy receptor 3 (DcR3)) is a new member of the tumor necrosis factor receptor (TNFR) family. TR6 mRNA is expressed in lung tissues and colon adenocarcinoma, SW480. In addition, the expression of TR6 mRNA was shown in the endothelial
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